Select therapeutic use:

Breast cancer:

Indications for Megestrol Tablets:

Palliative treatment of advanced breast carcinoma.

Adult Dosage:

40mg 4 times daily.

Children Dosage:

Not applicable.

Megestrol Tablets Contraindications:

Pregnancy.

Megestrol Tablets Warnings/Precautions:

History of thromboembolic disease. Diabetes. Monitor for adrenal insufficiency. Fetal toxicity. Obtain (–) pregnancy test prior to initiation. Advise females of reproductive potential to use effective contraception during therapy. Nursing mothers: not recommended.

Megestrol Tablets Classification:

Progestin.

Megestrol Tablets Interactions:

May increase insulin requirements. Decreases indinavir levels.

Adverse Reactions:

Weight gain, thromboembolic events, heart failure, GI upset, edema, breakthrough menstrual bleeding, dyspnea, tumor flare, hyperglycemia, alopecia, hypertension, carpal tunnel syndrome, mood changes, hot flashes, malaise, asthenia, lethargy, sweating, rash.

Note:

Formerly known under the brand name Megace.

How Supplied:

Contact supplier.

Gynecologic cancers:

Indications for Megestrol Tablets:

Palliative treatment of advanced endometrial carcinoma.

Adult Dosage:

40–320mg daily in divided doses.

Children Dosage:

Not applicable.

Megestrol Tablets Contraindications:

Pregnancy.

Megestrol Tablets Warnings/Precautions:

History of thromboembolic disease. Diabetes. Monitor for adrenal insufficiency. Fetal toxicity. Obtain (–) pregnancy test prior to initiation. Advise females of reproductive potential to use effective contraception during therapy. Nursing mothers: not recommended.

Megestrol Tablets Classification:

Progestin.

Megestrol Tablets Interactions:

May increase insulin requirements. Decreases indinavir levels.

Adverse Reactions:

Weight gain, thromboembolic events, heart failure, GI upset, edema, breakthrough menstrual bleeding, dyspnea, tumor flare, hyperglycemia, alopecia, hypertension, carpal tunnel syndrome, mood changes, hot flashes, malaise, asthenia, lethargy, sweating, rash.

Note:

Formerly known under the brand name Megace.

How Supplied:

Contact supplier.