Mefloquine Tablets

  • Malaria

Mefloquine Tablets Generic Name & Formulations

General Description

Mefloquine (as HCl) 250mg; scored tabs.

Pharmacological Class


How Supplied

Contact supplier.

Mefloquine Tablets Indications


Prophylaxis of P. falciparum (including chloroquine-resistant strains) and P. vivax malaria. Treatment of mild to moderate acute malaria due to susceptible strains of P. falciparum or P. vivax.

Mefloquine Tablets Dosage and Administration


Take with food and 8oz water. Prophylaxis: 250mg once weekly starting 1 week before departure, continuing during travel to endemic areas and for 4 weeks after return. Treatment: 1250mg as a single dose.


Give with food and water. May crush tab and mix in water. Prophylaxis: 3–5mg/kg once weekly starting 1 week before departure, continuing during travel to endemic areas and for 4 weeks after return. Treatment: ≤6months of age: contact manufacturer. ≥6months: 20–25mg/kg as single dose or as 2 doses 6–8 hours apart.

Mefloquine Tablets Contraindications


Quinine, quinidine, or related allergy. Not for prophylactic use in patients with psychiatric disorders or history of depression or seizures.

Mefloquine Tablets Boxed Warnings

Not Applicable

Mefloquine Tablets Warnings/Precautions


Do not use for life-threatening P. falciparum infection. After initial treatment for acute P. vivax infection, follow with an 8-aminoquinoline (eg, primaquine) to eliminate exoerythrocytic phase. Discontinue prophylactic therapy if unexplained CNS disturbances occur. Cardiac disease. Psychiatric disturbances. Seizure disorders. Hepatic impairment. Monitor liver, visual function in long-term use. Pregnancy (Cat.C); use adequate contraception. Nursing mothers: not recommended.

Mefloquine Tablets Pharmacokinetics

See Literature

Mefloquine Tablets Interactions


Do not use during or within 12 hours of quinine, quinidine, chloroquine (may cause seizures or ECG changes); caution with drugs that cause QTc prolongation (eg, β-blockers). Do not use halofantrine or ketoconazole during or within 15 weeks of last mefloquine dose. Caution with rifampin. May affect or be affected by CYP3A4 inhibitors or inducers, p-glycoprotein substrates. May antagonize antiepileptics. Complete live oral bacterial vaccinations (eg, typhoid) at least 3 days before 1st mefloquine dose. Monitor anticoagulants, antidiabetics, antiepileptics 2–3 weeks before departure.

Mefloquine Tablets Adverse Reactions

Adverse Reactions

Vomiting, dizziness, vertigo, syncope, extrasystoles, myalgias, fever, headache, chills, diarrhea, rash, abdominal pain, fatigue, anorexia, tinnitus; rare: seizures, cardiac arrest, encephalopathy, CNS/emotional disturbances.

Mefloquine Tablets Clinical Trials

See Literature

Mefloquine Tablets Note

Not Applicable

Mefloquine Tablets Patient Counseling

See Literature