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Maxipime Generic Name & Formulations
Legal Class
Rx
General Description
Cefepime (as HCl) 500mg, 1g, 2g; pwd for IV infusion or IM inj after reconstitution.
Pharmacological Class
Cephalosporin.
How Supplied
Vials (500mg)—10; 1g, 2g—10, 25
Manufacturer
Generic Availability
YES
Maxipime Indications
Indications
Susceptible infections, including moderate to severe pneumonia, uncomplicated skin and skin structure infections, complicated and uncomplicated urinary tract infections (UTIs) including pyelonephritis, complicated intraabdominal in adults (w. metronidazole). Empiric therapy in febrile neutropenia.
Maxipime Dosage and Administration
Adult
When giving IV, infuse over 30mins. Pneumonia: 1–2g IV every 8–12hrs for 10 days. Skin and skin structures, severe UTIs: 2g IV every 12hrs for 10 days. Mild to moderate UTIs: 500mg–1g IV or IM every 12hrs for 7–10 days (IM only for UTIs caused by E. coli). Intraabdominal (use w. metronidazole): 2g IV every 8–12hrs for 7–10 days. Febrile neutropenia: 2g IV every 8hrs for 7 days or until neutropenia resolves. CrCl ≤60mL/min: reduce dose; see full labeling. Hemodialysis: give dose after each session. Continuous ambulatory peritoneal dialysis: give usual doses at 48hr intervals.
Children
<2mos: not established. Not for use in serious infection when pathogen is or may be H. influenzae type b. 2mos–16yrs (≤40kg): 50mg/kg/dose every 12hrs (every 8hrs for P. aeruginosa pneumonia); do not exceed recommended adult dose. Severe UTIs, pneumonia, skin and skin structure: give IV for 10 days. Mild to moderate UTIs: give IV or IM for 7–10 days (IM only for UTIs caused by E. coli). Febrile neutropenia: give IV every 8hrs for 7 days or until neutropenia resolves.
Maxipime Contraindications
Contraindications
Penicillin or other β-lactam allergy.
Maxipime Boxed Warnings
Not Applicable
Maxipime Warnings/Precautions
Warnings/Precautions
Renal impairment. Risk of neurotoxicity (esp. in renally-impaired); discontinue if occurs and treat appropriately. Renal or hepatic dysfunction, poor nutritional state, prolonged antimicrobial therapy: monitor prothrombin time. History of GI disease (esp. colitis). Pregnancy. Nursing mothers.
Maxipime Pharmacokinetics
See Literature
Maxipime Interactions
Interactions
Aminoglycosides may potentiate oto- or nephrotoxicity. Possible nephrotoxicity with diuretics (eg, furosemide). May cause false (+) Coomb's, Clinitest.
Maxipime Adverse Reactions
Adverse Reactions
Local reactions (eg, pain, phlebitis, inflammation), rash, nausea, vomiting, diarrhea, pruritus, fever, headache, anemia, renal dysfunction; neurotoxicity, C. difficile associated diarrhea, hypersensitivity reactions.
Maxipime Clinical Trials
See Literature
Maxipime Note
Not Applicable
Maxipime Patient Counseling
See Literature
