Maprotiline Hcl

  • Mood disorders

Maprotiline Hcl Generic Name & Formulations

General Description

Maprotiline HCl 25mg, 50mg, 75mg; tabs.

Pharmacological Class


How Supplied



Maprotiline Hcl Indications


Treatment of depressive illness in patients with depressive neurosis (dysthymic disorder) and manic-depressive illness, depressed type (major depressive disorder). Relief of anxiety associated with depression.

Maprotiline Hcl Dosage and Administration


Mild-moderate depression: initially 75mg daily; maintain for 2 weeks, may increase in 25mg increments as required and tolerated. Usual max 150mg daily. Severely depressed or hospitalized: initially 100–150mg daily; may increase to max 225mg daily if necessary. Maintenance: use lowest effective dose; may be reduced to 75–150mg daily; adjust as needed. Elderly (>60yrs): initially 25mg daily; maintenance therapy: 50–75mg daily.


<18yrs: not recommended.

Maprotiline Hcl Contraindications


Seizure disorder. Within 14 days of MAOIs. Acute phase of MI.

Maprotiline Hcl Boxed Warnings

Not Applicable

Maprotiline Hcl Warnings/Precautions


History of MI. Cardiovascular disease. Discontinue prior to elective surgery. Increased intraocular pressure. Urinary retention. Narrow-angle glaucoma. Hyperthyroidism. Monitor leukocyte and differential counts in patients who develop fever and sore throat; discontinue if evidence of pathological neutrophil depression. Write ℞ for smallest amount needed. Pregnancy (Cat.B). Nursing mothers.

Maprotiline Hcl Pharmacokinetics

See Literature

Maprotiline Hcl Interactions


See Contraindications. Potentiates CNS depression with concomitant alcohol, barbiturates, other CNS depressants. Additive atropine-like effects with anticholinergics, sympathomimetics. Avoid concomitant electroshock therapy. Potential for cardiovascular toxicity with thyroid drugs. May antagonize guanethidine. Concomitant phenothiazines, or rapid tapering of benzodiazepines: increased risk of seizures. May be potentiated by hepatic enzyme inhibitors (eg, cimetidine, fluoxetine). May be antagonized by hepatic enzyme inducers (eg, barbiturates, phenytoin).

Maprotiline Hcl Adverse Reactions

Adverse Reactions

Drowsiness, dry mouth, nervousness, dizziness, constipation, blurred vision, tremor, GI upset, anxiety, insomnia, weakness, fatigue, headache, agitation.

Maprotiline Hcl Clinical Trials

See Literature

Maprotiline Hcl Note


Formerly known under the brand name Ludiomil.

Maprotiline Hcl Patient Counseling

See Literature