Magnesium Sulfate Injection

  • Vitamins, minerals, supplements

Magnesium Sulfate Injection Generic Name & Formulations

General Description

Magnesium sulfate 500mg/mL; soln for IM inj; or IV use after dilution; contains aluminum.

How Supplied

Contact supplier.

Magnesium Sulfate Injection Indications


Magnesium deficiency.

Magnesium Sulfate Injection Dosage and Administration


Mild deficiency: 1g IM every 6 hours for four doses. Severe deficiency: 250mg/kg IM within a period of 4 hours if necessary; alternatively 5g may be added to one liter of 5% dextrose inj or 0.9% sodium chloride inj for slow IV infusion over a 3-hour period. TPN: usual range: 1–3g (8–24mEq) daily. Severe renal impairment: max 20g in 48 hours.


TPN for infants: usual range: 0.25–1.25g (2–10mEq) daily.

Magnesium Sulfate Injection Contraindications


Heart block. Myocardial damage.

Magnesium Sulfate Injection Boxed Warnings

Not Applicable

Magnesium Sulfate Injection Warnings/Precautions


Renal impairment. Monitor serum magnesium levels; if repeated doses are given, test knee jerk reflexes before each dose. Have injectable calcium salt readily available to counteract magnesium intoxication. Elderly. Premature neonates. Pregnancy (Cat.D). Nursing mothers.

Magnesium Sulfate Injection Pharmacokinetics

See Literature

Magnesium Sulfate Injection Interactions


Additive CNS depressant effects with barbiturates, narcotics, other hypnotics; adjust dose. Potentiates neuromuscular blocking agents. Concomitant cardiac glycosides; use extreme caution, heart block may occur.

Magnesium Sulfate Injection Adverse Reactions

Adverse Reactions

Magnesium intoxication (eg, flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and CNS depression proceeding to respiratory paralysis.

Magnesium Sulfate Injection Clinical Trials

See Literature

Magnesium Sulfate Injection Note


Formerly known under the brand name Sulfamag.

Magnesium Sulfate Injection Patient Counseling

See Literature