Macrobid Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Mechanism of Action
Macrobid Indications
Indications
For the treatment of acute uncomplicated urinary tract infections (acute cystitis) caused by susceptible strains of Escherichia coli or Staphylococcus saprophyticus.
Limitations of Use
Not indicated for the treatment of pyelonephritis or perinephric abscesses.
Macrobid Dosage and Administration
Adult
Children
Renal Impairment
Nitrofurantoin is substantially excreted by the kidney; risk of toxic reactions is increased in patients with impaired renal function.
Anuria, oliguria, or significant renal impairment (CrCl<60mL/min or clinically significant elevated serum creatinine) are contraindications.
It may be useful to monitor renal function in elderly patients.
Administration
To enhance tolerance and improve drug absorption, Macrobid should be taken with food (ideally breakfast and dinner).
Macrobid Contraindications
Contraindications
Macrobid Boxed Warnings
Not Applicable
Macrobid Warnings/Precautions
Warnings/Precautions
Macrobid Pharmacokinetics
Absorption
Bioavailability of nitrofurantoin is increased by ~40% when administered with food.
Distribution
Up to 90% serum protein bound.
Elimination
Macrobid Interactions
Interactions
Macrobid Adverse Reactions
Adverse Reactions
Macrobid Clinical Trials
Macrobid Note
Not Applicable