Select therapeutic use:

Fibromyalgia:

Indications for LYRICA:

Fibromyalgia.

Adult:

Initially 75mg twice daily, may increase to 150mg twice daily within 1 week as tolerated; max 450mg/day. Renal impairment (CrCl <60mL/min): reduce dose (see full labeling); hemodialysis: give supplemental dose after session.

Children:

<4yrs: not established. Give in 2–3 divided doses. ≥4yrs (11kg–<30kg): initially 3.5mg/kg/day, max 14mg/kg/day; (≥30kg): initially 2.5mg/kg/day, max 10mg/kg/day (up to 600mg/day). Renal impairment (CrCl <60mL/min): not established.

Warnings/Precautions:

Avoid abrupt cessation (taper over ≥1 week). Discontinue if angioedema, hypersensitivity reactions, myopathy or markedly elevated creatine kinase levels occur. Monitor for new or worsening depression, suicidal thoughts, unusual behavior. CHF. Ocular conditions. Diabetes (monitor skin integrity). Pregnancy. Nursing mothers: not recommended.

Pharmacologic Class:

Alpha-2 delta ligand.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Additive edema, weight gain with thiazolidinediones. Increased risk of angioedema with concomitant ACEIs.

Adverse Reactions:

Dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal (primarily difficulty with concentration/attention); elevated creatine kinase, decreased platelets, PR prolongation, male-mediated teratogenicity; may be tumorigenic. Also in children: increased appetite.

Note:

Register patients in North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling (888) 233-2334.

How Supplied:

Caps—90; CR tabs—30; Soln—16oz

Pricing for LYRICA

75mg capsule (Qty: 60)
Appx. price $472
GoodRx

Nonnarcotic analgesics:

Indications for LYRICA:

Neuropathic pain associated with diabetic peripheral neuropathy (DPN) or spinal cord injury. Postherpetic neuralgia (PHN).

Adult:

DPN: initially 50mg 3 times daily, may increase to 100mg 3 times daily within 1 week. Spinal cord injury: initially 75mg twice daily, may increase to 150mg twice daily within 1 week, then max 600mg/day after 2 weeks as tolerated. PHN: initially 75mg twice daily or 50mg 3 times daily; max 300mg/day after 1 week then 600mg/day after 2 weeks as tolerated (see full labeling). For all: renal impairment (CrCl <60mL/min): reduce dose (see full labeling); hemodialysis: give supplemental dose after session.

Children:

<4yrs: not established. Give in 2–3 divided doses. ≥4yrs (11kg–<30kg): initially 3.5mg/kg/day, max 14mg/kg/day; (≥30kg): initially 2.5mg/kg/day, max 10mg/kg/day (up to 600mg/day). Renal impairment (CrCl <60mL/min): not established.

Warnings/Precautions:

Avoid abrupt cessation (taper over ≥1 week). Discontinue if angioedema, hypersensitivity reactions, myopathy or markedly elevated creatine kinase levels occur. Monitor for new or worsening depression, suicidal thoughts, unusual behavior. CHF. Ocular conditions. Diabetes (monitor skin integrity). Pregnancy. Nursing mothers: not recommended.

Pharmacologic Class:

Alpha-2 delta ligand.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Additive edema, weight gain with thiazolidinediones. Increased risk of angioedema with concomitant ACEIs.

Adverse Reactions:

Dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal (primarily difficulty with concentration/attention); elevated creatine kinase, decreased platelets, PR prolongation, male-mediated teratogenicity; may be tumorigenic. Also in children: increased appetite.

Note:

Register patients in North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling (888) 233-2334.

How Supplied:

Caps—90; CR tabs—30; Soln—16oz

Pricing for LYRICA

75mg capsule (Qty: 60)
Appx. price $472
GoodRx

Seizure disorders:

Indications for LYRICA:

Adjunct in partial onset seizures.

Adult:

Give in 2–3 divided doses. ≥17yrs: initially 150mg/day; max 600mg/day. Renal impairment (CrCl <60mL/min): reduce dose (see full labeling); hemodialysis: give supplemental dose after session.

Children:

<4yrs: not established. Give in 2–3 divided doses. ≥4yrs (11kg–<30kg): initially 3.5mg/kg/day, max 14mg/kg/day; (≥30kg): initially 2.5mg/kg/day, max 10mg/kg/day (up to 600mg/day). Renal impairment (CrCl <60mL/min): not established.

Warnings/Precautions:

Avoid abrupt cessation (taper over ≥1 week). Discontinue if angioedema, hypersensitivity reactions, myopathy or markedly elevated creatine kinase levels occur. Monitor for new or worsening depression, suicidal thoughts, unusual behavior. CHF. Ocular conditions. Diabetes (monitor skin integrity). Pregnancy. Nursing mothers: not recommended.

Pharmacologic Class:

Alpha-2 delta ligand.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Additive edema, weight gain with thiazolidinediones. Increased risk of angioedema with concomitant ACEIs.

Adverse Reactions:

Dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal (primarily difficulty with concentration/attention); elevated creatine kinase, decreased platelets, PR prolongation, male-mediated teratogenicity; may be tumorigenic. Also in children: increased appetite.

Note:

Register patients in North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling (888) 233-2334.

How Supplied:

Caps—90; CR tabs—30; Soln—16oz

Pricing for LYRICA

75mg capsule (Qty: 60)
Appx. price $472
GoodRx