Lupron Depot 7.5mg

  • Prostate and other male cancers

Lupron Depot 7.5mg Generic Name & Formulations

General Description

Leuprolide acetate 7.5mg; depot susp for IM inj; preservative-free.

Pharmacological Class

GnRH analogue.

How Supplied

Depot kit—1 (prefilled dual-chamber syringe w. supplies)


Lupron Depot 7.5mg Indications


Palliative treatment of advanced prostatic carcinoma.

Lupron Depot 7.5mg Dosage and Administration


Give as single IM inj into gluteal area, anterior thigh or deltoid; rotate inj sites. 7.5mg once a month (4 weeks).


Not applicable.

Lupron Depot 7.5mg Contraindications

Not Applicable

Lupron Depot 7.5mg Boxed Warnings

Not Applicable

Lupron Depot 7.5mg Warnings/Precautions


Initial worsening of signs/symptoms (eg, bone pain, ureteral obstruction, spinal cord compression) may occur; monitor closely in metastatic vertebral lesions, urinary obstruction, hematuria. Monitor serum testosterone, PSA. Increased risk of diabetes, MI, sudden cardiac death, stroke; monitor blood glucose, HbA1c, and for signs/symptoms of CVD during therapy. Increased risk of convulsions in patients with history of seizures, epilepsy, cerebrovascular disorder, CNS anomalies or tumors. Risk of QT prolongation in long-term androgen deprivation therapy, congenital long QT syndrome, electrolyte abnormalities (correct and monitor), or CHF; consider monitoring ECGs. Instruct patient on correct self administration. Embryo-fetal toxicity. Pregnancy. Nursing mothers: not recommended.

Lupron Depot 7.5mg Pharmacokinetics

See Literature

Lupron Depot 7.5mg Interactions


Concomitant antiarrhythmics may prolong the QT interval. Risk of seizures with concomitant SSRIs, bupropion, others.

Lupron Depot 7.5mg Adverse Reactions

Adverse Reactions

Hot flashes/sweats, pain, GI disorders, edema, respiratory disorder, urinary disorders, inj site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue; tumor flare, hyperglycemia, convulsions, hypersensitivity.

Lupron Depot 7.5mg Clinical Trials

See Literature

Lupron Depot 7.5mg Note

Not Applicable

Lupron Depot 7.5mg Patient Counseling

See Literature