Lupron Depot 7.5mg Generic Name & Formulations
Legal Class
Rx
General Description
Leuprolide acetate 7.5mg; depot susp for IM inj; preservative-free.
Pharmacological Class
GnRH analogue.
How Supplied
Depot kit—1 (prefilled dual-chamber syringe w. supplies)
Manufacturer
Lupron Depot 7.5mg Indications
Indications
Palliative treatment of advanced prostatic carcinoma.
Lupron Depot 7.5mg Dosage and Administration
Adult
Give as single IM inj into gluteal area, anterior thigh or deltoid; rotate inj sites. 7.5mg once a month (4 weeks).
Children
Not applicable.
Lupron Depot 7.5mg Contraindications
Not Applicable
Lupron Depot 7.5mg Boxed Warnings
Not Applicable
Lupron Depot 7.5mg Warnings/Precautions
Warnings/Precautions
Initial worsening of signs/symptoms (eg, bone pain, ureteral obstruction, spinal cord compression) may occur; monitor closely in metastatic vertebral lesions, urinary obstruction, hematuria. Monitor serum testosterone, PSA. Increased risk of diabetes, MI, sudden cardiac death, stroke; monitor blood glucose, HbA1c, and for signs/symptoms of CVD during therapy. Increased risk of convulsions in patients with history of seizures, epilepsy, cerebrovascular disorder, CNS anomalies or tumors. Risk of QT prolongation in long-term androgen deprivation therapy, congenital long QT syndrome, electrolyte abnormalities (correct and monitor), or CHF; consider monitoring ECGs. Instruct patient on correct self administration. Embryo-fetal toxicity. Pregnancy. Nursing mothers: not recommended.
Lupron Depot 7.5mg Pharmacokinetics
See Literature
Lupron Depot 7.5mg Interactions
Interactions
Concomitant antiarrhythmics may prolong the QT interval. Risk of seizures with concomitant SSRIs, bupropion, others.
Lupron Depot 7.5mg Adverse Reactions
Adverse Reactions
Hot flashes/sweats, pain, GI disorders, edema, respiratory disorder, urinary disorders, inj site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue; tumor flare, hyperglycemia, convulsions, hypersensitivity.
Lupron Depot 7.5mg Clinical Trials
See Literature
Lupron Depot 7.5mg Note
Not Applicable
Lupron Depot 7.5mg Patient Counseling
See Literature