• Sleep-wake disorders

Lunesta Generic Name & Formulations

General Description

Eszopiclone 1mg, 2mg, 3mg; tabs.

Pharmacological Class

Pyrrolopyrazine hypnotic.

How Supplied

Tabs 1mg—30; 2mg, 3mg—30, 100


Generic Availability


Lunesta Indications


Insomnia (decreased sleep latency and improved sleep maintenance).

Lunesta Dosage and Administration


Use lowest effective dose. Effects delayed if taken with or after a heavy/high-fat meal. ≥18yrs: initially 1mg immediately before bedtime (with at least 7–8hrs remaining before planned time of awakening); may increase to 2–3mg if needed; max 3mg/dose. Elderly, debilitated, concomitant CYP3A4 inhibitors, or severe hepatic impairment: max 2mg/dose.


<18yrs: not established.

Lunesta Contraindications


Prior history of complex sleep behaviors with Lunesta.

Lunesta Boxed Warnings

Boxed Warning

Complex sleep behaviors.

Lunesta Warnings/Precautions


Risk of complex sleep behaviors (eg, sleep-walking, sleep-driving, engaging in other activities while not fully awake); discontinue immediately if occur. Monitor for CNS depressant effects and next-day impairment. Evaluate for co-morbid diagnoses (eg, physical and/or psychiatric disorders) prior to treatment. Reevaluate if insomnia fails to remit after 7–10 days of use. Depression. Suicidal tendencies. Evaluate any new onset of behavioral changes. Compromised respiratory function. Conditions that affect metabolism or hemodynamic response. Drug or alcohol abuse. Hepatic impairment. Avoid abrupt cessation. Write ℞ for smallest practical amount. Elderly (higher risk of falls). Debilitated. Pregnancy. Nursing mothers.

Lunesta Pharmacokinetics

See Literature

Lunesta Interactions


Concomitant other sedative-hypnotics at bedtime or middle of the night: not recommended. Potentiates CNS depression with alcohol, other CNS depressants; adjust dose. Potentiated by CYP3A4 inhibitors (eg, ketoconazole, itraconazole, clarithromycin, nefazodone, troleandomycin, ritonavir, nelfinavir); see Adults. May be antagonized by CYP3A4 inducers (eg, rifampicin).

Lunesta Adverse Reactions

Adverse Reactions

Unpleasant taste, headache, somnolence, dizziness, dry mouth, infection, rash, anxiety, hallucinations; abnormal thinking and behavioral changes; rare: anaphylaxis, angioedema (do not rechallenge).

Lunesta Clinical Trials

See Literature

Lunesta Note

Not Applicable

Lunesta Patient Counseling

See Literature