Lumryz Generic Name & Formulations
Mechanism of Action
Sodium oxybate is the sodium salt of gamma-hydroxybutyrate (GHB), an endogenous compound and metabolite of the neurotransmitter GABA. It is hypothesized that its therapeutic effects on cataplexy and excessive daytime sleepiness are mediated through GABAB actions at noradrenergic and dopaminergic neurons, as well as at thalamocortical neurons.
Lumryz Dosage and Administration
Take ≥2hrs after eating. Mix each dose with ~80mL of water. Initially 4.5g/night as a single dose. May increase by 1.5g/night at weekly intervals; usual range: 6–9g/night; max 9g/night. Switch from immediate-release sodium oxybate: use nearest equivalent dose in g/night. Allow 6hrs before becoming active after last dose.
Lumryz Boxed Warnings
CNS depression. Abuse and misuse.
- Peak plasma concentrations after one 6g dose: 66 mcg/mL.
- Time to peak plasma concentration after one 6g dose: 1.5 hours.
- Apparent volume of distribution: 190–384 mL/kg.
- Renal (<5%). Half-life: 0.5–1 hour.
Lumryz Adverse Reactions
Nausea, dizziness, enuresis, headache, vomiting; CNS and respiratory depression, sleep-disordered breathing, sleepwalking, depressive symptoms, confusion, anxiety, other behavioral/psychiatric reactions.
Lumryz Clinical Trials
Lumryz Patient Counseling