• Hypertension

Lotensin Generic Name & Formulations

General Description

Benazepril (as HCl) 5mg, 10mg, 20mg, 40mg; tabs.

Pharmacological Class

ACE inhibitor.

How Supplied


Generic Availability


Lotensin Indications



Lotensin Dosage and Administration


If not on diuretic: initially 10mg once daily. Usual maintenance: 20–40mg daily in 1 or 2 divided doses; usual max 80mg/day. If on diuretic: initially 5mg once daily. If BP not controlled on benazepril alone, may add low dose diuretic. CrCl<30mL/min/1.73m2: initially 5mg daily; max 40mg/day.


<6yrs or CrCl<30mL/min/1.73m2: not recommended. ≥6yrs: Initially 0.2mg/kg daily; usual max 0.6mg/kg/day (or 40mg/day). Prepare suspension if unable to swallow tablets or if calculated mg/kg dosage does not correspond to available tablet strengths (see full labeling).

Lotensin Contraindications


History of ACEI-associated or other angioedema. Concomitant neprilysin inhibitors (eg, sacubitril); do not administer benazepril within 36hrs of switching to or from sacubitril/valsartan. Concomitant aliskiren in patients with diabetes.

Lotensin Boxed Warnings

Boxed Warning

Fetal toxicity.

Lotensin Warnings/Precautions


Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion prior to initiation. CHF. Renal impairment. Dialysis (esp. high-flux membrane). Renal artery stenosis. Surgery. Diabetes. Discontinue and treat if angioedema, laryngeal edema, jaundice or marked elevation of hepatic enzymes develop. Monitor BP, electrolytes, and renal function. Black patients may have higher rate of angioedema than non-black patients. Elderly. Neonates. Pregnancy: monitor. Nursing mothers.

Lotensin Pharmacokinetics

See Literature

Lotensin Interactions


See Contraindications. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Avoid concomitant aliskiren in renal impairment (CrCl <60mL/min). Hyperkalemia with K+-sparing diuretics, K+ supplements, or K+-containing salt substitutes. May increase lithium levels. Potentiated by diuretics. May be antagonized by, and renal toxicity potentiated by, NSAIDs, including selective COX-2 inhibitors (monitor renal function periodically in elderly and/or volume depleted). Increased risk of angioedema with concomitant mTOR inhibitors (eg, temsirolimus, sirolimus, everolimus) or neprilysin inhibitors. Increased risk of hypoglycemia with insulins, oral hypoglycemic agents. Nitritoid reactions with concomitant injectable gold (eg, sodium aurothiomalate); rare.

Lotensin Adverse Reactions

Adverse Reactions

Headache, dizziness, fatigue, GI upset, cough, angioedema, orthostatic hypotension, hyperkalemia; rare: hepatic failure.

Lotensin Clinical Trials

See Literature

Lotensin Note

Not Applicable

Lotensin Patient Counseling

See Literature