Lopressor Injection

  • CHF and arrhythmias

Lopressor Injection Generic Name & Formulations

General Description

Metoprolol tartrate 5mg; soln for IV inj.

Pharmacological Class


See Also

How Supplied

Tabs—100; Ampuls (5mL)—10

Lopressor Injection Indications


In stabilized patients after MI, to reduce mortality.

Lopressor Injection Dosage and Administration


See literature. Early treatment: initially administer three 5mg IV bolus inj given at approximately 2-minute intervals; monitor BP, HR, ECG. If full IV dose (15mg) tolerable, give 50mg (tab) every 6 hours starting 15 mins after the last IV dose and continue for 48 hours, thereafter, give maintenance dose of 100mg (tab) twice daily; if full IV dose not tolerable, give 25–50mg (tab) every 6 hours starting 15 mins after the last IV dose or as soon as clinical condition allows; if severe intolerance: discontinue treatment. Late treatment: if early phase treatment is contraindicated, intolerable or delayed therapy needed, start with 100mg (tab) twice daily for at least three months.


Not recommended.

Lopressor Injection Contraindications


Significant 1st degree heart block. 2nd- or 3rd-degree AV block. Systolic pressure<100mmHg or heart rate <45 beats/min. Moderate-to-severe cardiac failure.

Lopressor Injection Boxed Warnings

Boxed Warning

Avoid abrupt discontinuation in ischemic heart disease.

Lopressor Injection Warnings/Precautions


CHF. Monitor heart rate and rhythm; reduce or stop treatment if severe bradycardia develops. Bronchospastic disease. Hepatic dysfunction. Diabetes. Pheochromocytoma. Hyperthyroidism. Surgery. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.

Lopressor Injection Pharmacokinetics

See Literature

Lopressor Injection Interactions


Bradycardia with catecholamine-depleting drugs. May be potentiated by potent CYP2D6 inhibitors (eg, fluoxetine, paroxetine, bupropion, thioridazine, quinidine, propafenone, ritonavir, diphenhydramine, hydroxychloroquine, terbinafine, cimetidine), hydralazine, inhalation anesthetics. Increased risk of bradycardia with concomitant digitalis. May block epinephrine. Increased rebound hypertension with clonidine withdrawal. May enhance vasoconstrictive action of ergots. Withhold before dipyridamole testing.

Lopressor Injection Adverse Reactions

Adverse Reactions

Fatigue, dizziness, depression, hypotension (discontinue if occurs), diarrhea, rash, dyspnea, bradycardia, cold extremities, palpitations, CHF, peripheral edema, bronchospasm, heart block.

Lopressor Injection Clinical Trials

See Literature

Lopressor Injection Note

Not Applicable

Lopressor Injection Patient Counseling

See Literature