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Lopressor Hct Generic Name & Formulations
Legal Class
Rx
General Description
Metoprolol tartrate, hydrochlorothiazide 50mg/25mg; scored tabs.
Pharmacological Class
Cardioselective beta-blocker + diuretic.
How Supplied
Tabs—100
Manufacturer
Generic Availability
YES
Lopressor Hct Indications
Indications
Hypertension.
Lopressor Hct Dosage and Administration
Adult
Titrate individual components. Give in 1–2 divided doses. Max 50mg/day HCTZ.
Children
Not established.
Lopressor Hct Contraindications
Contraindications
Cardiogenic shock. Decompensated heart failure. Sinus bradycardia. Sick-sinus syndrome. Greater than 1st-degree block, unless paced. Anuria. Sulfonamide allergy.
Lopressor Hct Boxed Warnings
Not Applicable
Lopressor Hct Warnings/Precautions
Warnings/Precautions
Ischemic heart disease. Worsening cardiac failure (reduce or interrupt dose if necessary). Bronchospastic disease. Conduction disorders (including Wolff-Parkinson-White). Monitor HR; reduce dose or discontinue if severe bradycardia occurs. Major surgery. Renal or hepatic impairment. Volume depletion. Diabetes and hypoglycemia. Monitor serum electrolytes periodically. Peripheral vascular disease. Pheochromocytoma. Thyrotoxicosis (hyperthyroidism). History of severe anaphylactic reactions. Acute myopia. Secondary angle-closure glaucoma. SLE. Gout. Avoid abrupt cessation (gradually reduce dose over 1–2 weeks and monitor). Elderly. Pregnancy. Nursing mothers: monitor infants.
Lopressor Hct Pharmacokinetics
See Literature
Lopressor Hct Interactions
Interactions
Additive effects with catecholamine-depleting drugs (eg, reserpine, monoamine oxidase). Potentiated by strong CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine, propafenone); monitor closely if concomitant use is unavoidable. Risk of bradycardia with digitalis, clonidine, diltiazem, verapamil. Potentiated by alcohol, CNS depressants, other antihypertensives. Adjust antidiabetic medication. Decreased absorption with cholestyramine and colestipol resins. Beta-blockers may mask signs of hypoglycemia. May increase lithium toxicity. Antagonized by NSAIDs. May antagonize epinephrine.
Lopressor Hct Adverse Reactions
Adverse Reactions
Fatigue, bronchospasm, dizziness, drowsiness, headache, fluid or electrolyte imbalance, bradycardia, depression, dyspnea, GI upset, blurred vision, tinnitus, earache, impotence, myalgia, cold extremities, CHF, heart block.
Lopressor Hct Clinical Trials
See Literature
Lopressor Hct Note
Not Applicable
Lopressor Hct Patient Counseling
See Literature
