• Colorectal and other GI cancers

Lonsurf Generic Name & Formulations

General Description

Trifluridine, tipiracil; 15mg/6.14mg, 20mg/8.19mg; tabs.

Pharmacological Class

Antineoplastic thymidine-based nucleoside analog + thymidine phosphorylase inhibitor.

How Supplied

Tabs—20, 40, 60


Generic Availability


Lonsurf Indications


Metastatic colorectal cancer in patients previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy. Metastatic gastric or gastroesophageal junction adenocarcinoma in patients previously treated with at least 2 prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, HER2/neu-targeted therapy.

Lonsurf Dosage and Administration


Swallow whole. Take with food. 35mg/m2 twice daily on Days 1–5 and 8–12 of each 28-day cycle until disease progression or unacceptable toxicity; max 80mg per dose (based on trifluridine component). Dose modifications: see full labeling.


Not established.

Lonsurf Contraindications

Not Applicable

Lonsurf Boxed Warnings

Not Applicable

Lonsurf Warnings/Precautions


Severe myelosuppression. Obtain CBC prior to and on Day 15 of each cycle, and as clinically indicated. Do not initiate cycle until ANC ≥1,500/mm3 or febrile neutropenia is resolved, platelets ≥75,000/mm3 or Grade 3/4 non-hematological adverse reactions resolved to Grade 0/1. Withhold dose if ANC <500/mm3 or febrile neutropenia, platelets <50,000/mm3, or Grade 3/4 non-hematological adverse reactions occur; upon recovery, resume at a reduced dose (see full labeling). Moderate or severe hepatic impairment: do not initiate. Severe renal impairment (CrCl <30mL/min) or ESRD: not studied. Embryo-fetal toxicity. Use effective contraception during and for ≥6 months (females) or ≥3 months (males w. female partners) after final dose. Pregnancy: exclude status prior to initiation. Nursing mothers: not recommended (during and for 1 day after final dose).

Lonsurf Pharmacokinetics

See Literature

Lonsurf Interactions

Lonsurf Adverse Reactions

Adverse Reactions

Anemia, neutropenia, asthenia/fatigue, nausea, thrombocytopenia, decreased appetite, diarrhea, vomiting, abdominal pain, pyrexia.

Lonsurf Clinical Trials

See Literature

Lonsurf Note

Not Applicable

Lonsurf Patient Counseling

See Literature