• Parkinsonism

Lodosyn Generic Name & Formulations

General Description

Carbidopa 25mg; scored tabs.

Pharmacological Class

Dopa-decarboxylase inhibitor.

How Supplied


Lodosyn Indications


Parkinsonism (in combination with Sinemet or levodopa).

Lodosyn Dosage and Administration


≥18yrs: Concomitant Sinemet 10-100: give Lodosyn 25mg with first dose of Sinemet each day; additional 12.5mg or 25mg doses may be given with each dose of Sinemet. Concomitant Sinemet 25-100 or 25-250: give Lodosyn 25mg with any dose of Sinemet as required for optimum therapeutic response. Max total daily dose of carbidopa: 200mg. Patients requiring individual titration of carbidopa and levodopa: initially Lodosyn 25mg 3–4 times daily with concomitant levodopa, starting with max 20-25% of previous or recommended daily dosage of levodopa when given without carbidopa; if patient already receiving levodopa therapy, allow 12hrs to elapse before initiating carbidopa with levodopa. May give Vit. B6 supplement. See full labeling for dosage adjustments, interruption of therapy.


<18yrs: not recommended.

Lodosyn Contraindications


During or within 14 days of nonselective MAOIs. Narrow-angle glaucoma.

Lodosyn Boxed Warnings

Not Applicable

Lodosyn Warnings/Precautions


With levodopa: Severe cardiovascular or pulmonary disease. Asthma. Renal, hepatic, or endocrine disorders. History of peptic ulcer or MI with residual arrhythmias. Suicidal tendencies. Psychosis. Orthostatic hypotension. Chronic wide-angle glaucoma. Monitor renal, liver, cardiovascular function, intraocular pressure, blood counts during extended therapy. May stain body fluids. Sleep disorders. Impulse control/compulsive behaviors; consider dose reduction or discontinue if occurs. Monitor for melanomas; perform skin exams. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Lodosyn Pharmacokinetics

See Literature

Lodosyn Interactions


With levodopa: See Contraindications. Orthostatic hypotension with selegiline, rasigiline, or antihypertensives; may need to adjust dose of antihypertensive. Antagonized by phenothiazines, butyrophenones, risperidone, phenytoin, papaverine. Hypertension, dyskinesia with tricyclic antidepressants. May be antagonized by iron, high protein diets. May cause false (+) urinary ketone test or false (–) urinary glucose (glucose oxidase) test.

Lodosyn Adverse Reactions

Adverse Reactions

With levodopa: Dyskinesia, nausea, hallucinations, confusion, psychological disturbances, depression, dizziness, headache, dream abnormalities, somnolence, sleepiness, dystonia, cardiac arrhythmias, hypotension, dyspnea, on-off phenomenon, back pain, blepharospasm (may indicate excess dosage), hypertension, anticholinergic effects, anorexia, insomnia, leukopenia, renal and liver function disorders, neuroleptic malignant syndrome.

Lodosyn Clinical Trials

See Literature

Lodosyn Note

Not Applicable

Lodosyn Patient Counseling

See Literature