Livmarli Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Livmarli Indications
Indications
Livmarli Dosage and Administration
Adults and Children
<3mos: not established. Use a calibrated measuring device. Give at 30mins before a meal in the AM. ≥3mos: initially 190mcg/kg once daily; after 1 week, increase to 380mcg/kg once daily, as tolerated. Max daily dose (patients >70kg): 3mL or 28.5mg/day. For individual dose volume by weight, dose modification for adverse events: see full labeling.
Livmarli Contraindications
Not Applicable
Livmarli Boxed Warnings
Not Applicable
Livmarli Warnings/Precautions
Warnings/Precautions
Livmarli Pharmacokinetics
Absorption
Maralixibat is minimally absorbed and plasma concentrations are often below the limit of quantification (0.25 ng/mL) after single or multiple doses at recommended doses. Following a single oral administration of maralixibat 30, 45, and 100 mg liquid formulation under fasted condition, AUClast and Cmax increased in a dose-dependent manner with increase of 4.6-and 2.4-fold, respectively, following a 3.3-fold dose increase from 30–100 mg.
Effect of Food: Concomitant administration of a high-fat meal with a single oral dose of maralixibat decreased both the rate and extent of absorption. AUC and Cmax of maralixibat values in the fed state were 64.8% to 85.8% lower relative to oral administration of 30 mg in fasted conditions.
Distribution
Plasma protein bound: 91%.
Elimination
Livmarli Interactions
Interactions
Livmarli Adverse Reactions
Adverse Reactions
Livmarli Clinical Trials
See Literature
Livmarli Note
Not Applicable
Livmarli Patient Counseling
See Literature
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