• Miscellaneous urogenital disorders

Lithostat Generic Name & Formulations

General Description

Acetohydroxamic acid 250mg; tabs.

Pharmacological Class

Urease inhibitor.

How Supplied


Lithostat Indications


As adjunctive therapy in chronic urea-splitting urinary infection.

Lithostat Dosage and Administration


Initially 12mg/kg per day every 6–8hrs; max 1.5g/day. Renal impairment: serum creatinine >1.8mg/dL: take at every 12-hour intervals; max 1g/day.


Initially 10mg/kg per day; monitor. Titrate doses to obtain therapeutic effects.

Lithostat Contraindications


Disease and physical state amenable to surgery and antimicrobials. Urine infected by non-urease producing organisms. Infections controllable by oral antimicrobials. Renal dysfunction (CrCl <20mL/min, serum creatinine >2.5mg/dL). Females with unsatisfactory method of contraception. Pregnancy (Cat.X).

Lithostat Boxed Warnings

Not Applicable

Lithostat Warnings/Precautions


Severe renal impairment: monitor and consider reduced dose. Monitor liver function. Preexisting thrombophlebitis or phlebothrombosis. Monitor and obtain CBCs with reticulocytes after 2 weeks of therapy and every 3 months thereafter; if reticulocytes >6%, consider reduced dose. Nursing mothers: not recommended.

Lithostat Pharmacokinetics

See Literature

Lithostat Interactions


Rash with concomitant alcohol. Concomitant dietary iron: may reduce absorption of both acetohydroxamic acid and iron (use IM inj form, if needed).

Lithostat Adverse Reactions

Adverse Reactions

Mild headaches, tremulousness, nervousness, depression, anxiety, GI upset, hemolytic anemia, mild reticulocytosis without anemia, rash, alopecia, phlebitis, palpitations.

Lithostat Clinical Trials

See Literature

Lithostat Note

Not Applicable

Lithostat Patient Counseling

See Literature