Hyperlipoproteinemias:

Indications for LIPOFEN:

Adjunct to diet in severe hypertriglyceridemia and to reduce elevated LDL-C, total-C, TG, and apo B, and to increase HDL-C, in primary hyperlipidemia or mixed dyslipidemia.

Limitations of Use:

Not shown to reduce coronary heart disease morbidity and mortality in patients with type 2 diabetes.

Adult:

Swallow whole. Take with food. Hypertriglyceridemia: 50–150mg/day, adjust at 4–8 week intervals; max 150mg/day. Hypercholesterolemia, dyslipidemia: 150mg/day. Mild to moderate renal impairment: initially 50mg/day. Discontinue if inadequate response after 2 months on max dose.

Children:

Not established.

Contraindications:

Severe renal impairment (including dialysis). Active liver disease. Unexplained persistent liver function abnormalities. Primary biliary cirrhosis. Gallbladder disease. Nursing mothers (during and for 5 days after last dose).

Warnings/Precautions:

Renal impairment; monitor. Monitor CBCs for first year; monitor liver function; discontinue if ALT (SGPT) levels >3×ULN persist. Discontinue if markedly elevated CPK levels, myopathy, gallstones, hypersensitivity reactions (acute and delayed), or severely depressed HDL levels occur. Elderly. Pregnancy.

Pharmacologic Class:

Fibrate.

Interactions:

Avoid statins. Potentiates oral anticoagulants (reduce anticoagulant dose and monitor PT/INR). Allow at least 1hr before or 4–6hrs after bile acid sequestrants. Caution with immunosuppressants (eg, cyclosporine, tacrolimus), colchicine, other nephrotoxic drugs.

Adverse Reactions:

Abnormal liver function tests, elevated CPK, respiratory or GI effects, myopathy, cholelithiasis, pancreatitis, hypersensitivity reactions (may be severe), rash; rare: rhabdomyolysis, transient hematologic changes, blood dyscrasias.

Generic Availability:

YES

How Supplied:

Caps—30, 90

Pricing for LIPOFEN

150mg capsule (Qty: 30)
Appx. price $159
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