Lipitor Generic Name & Formulations
Mechanism of Action
To reduce risk of MI, stroke, revascularization procedures, and angina in adults with multiple risk factors for coronary heart disease (CHD) but without clinically evident CHD. To reduce risk of MI and stroke in patients with type 2 diabetes with multiple risk factors for CHD but without clinically evident CHD. To reduce the risk of non-fatal MI, fatal and non-fatal stroke, revascularization procedures, hospitalization for CHF, and angina in patients with clinically evident CHD. Adjunct to diet to reduce LDL-C in: adults with primary hyperlipidemia; or patients aged ≥10yrs with heterozygous familial hypercholesterolemia (HeFH). Adjunct to other lipid-lowering therapies, or alone if such treatments are unavailable, to reduce LDL-C in patients aged ≥10yrs with homozygous familial hypercholesterolemia (HoFH). Adjunct to diet for adults with: primary dysbetalipoproteinemia; or hypertriglyceridemia.
Lipitor Dosage and Administration
Initially 10–20mg once daily; if more than a 45% reduction in LDL-C is needed, may start at 40mg once daily; range 10–80mg once daily. Concomitant clarithromycin, itraconazole, saquinavir + ritonavir, darunavir + ritonavir, fosamprenavir ± ritonavir, elbasvir + grazoprevir, letermovir: max 20mg/day. Concomitant nelfinavir: max 40mg/day.
HeFH or HoFH: <10yrs: not established. ≥10yrs: HeFH: initially 10mg/day; range 10–20mg once daily. HoFH: initially 10–20mg/day; range 10–80mg once daily. Concomitant clarithromycin, itraconazole, saquinavir + ritonavir, darunavir + ritonavir, fosamprenavir ± ritonavir, elbasvir + grazoprevir, letermovir: max 20mg/day. Concomitant nelfinavir: max 40mg/day.
Active liver disease or decompensated cirrhosis.
Lipitor Boxed Warnings
Risk for myopathy (eg, ≥65yrs of age, uncontrolled hypothyroidism, renal impairment, higher atorvastatin dose, concomitant certain drugs including other lipid-lowering therapies). Discontinue if markedly elevated CPK levels occur or if myopathy is diagnosed or suspected. Withhold dose in patients with acute or serious condition with high risk of developing renal failure secondary to rhabdomyolysis. Discontinue if immune-mediated necrotizing myopathy is suspected. Monitor liver function prior to starting therapy and repeat as clinically indicated. Discontinue immediately if serious hepatic injury, and/or hyperbilirubinemia, or jaundice occurs. History of liver disease. Substantial alcohol ingestion. Recent stroke or TIA: increased risk of hemorrhagic stroke (with atorvastatin 80mg dose). Elderly (monitor). Pregnancy: discontinue when recognized. Nursing mothers: not recommended.
Plasma protein bound: ≥98%.
Bile (primarily), renal (<2%). Half-life: ~14 hours.
Lipitor Adverse Reactions
Nasopharyngitis, arthralgia, diarrhea, pain in extremity, UTI; myopathy, rhabdomyolysis, elevated serum transaminases, increased HbA1c and fasting serum glucose, cognitive impairment, hypersensitivity reactions.
Lipitor Clinical Trials
Lipitor Patient Counseling