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Linzess Generic Name & Formulations
Legal Class
Rx
General Description
Linaclotide 72mcg, 145mcg, 290mcg; caps.
Pharmacological Class
Guanylate cyclase-C agonist.
How Supplied
Caps—30
Manufacturer
Generic Availability
NO
Linzess Indications
Indications
Irritable bowel syndrome with constipation (IBS-C).
Linzess Dosage and Administration
Adult
Swallow whole. Take on empty stomach, at least 30mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. 290mcg once daily.
Children
<2yrs: contraindicated. 2–<18yrs: not established.
Linzess Contraindications
Contraindications
Children <2yrs old. Known or suspected mechanical GI obstruction.
Linzess Boxed Warnings
Boxed Warning
Risk of serious dehydration in pediatric patients <2yrs of age.
Linzess Warnings/Precautions
Warnings/Precautions
Consider dose suspension and rehydration if severe diarrhea occurs. Pregnancy. Nursing mothers.
Linzess Pharmacokinetics
Elimination
Fecal.
Linzess Interactions
Linzess Adverse Reactions
Adverse Reactions
Diarrhea, abdominal pain, flatulence, abdominal distention.
Linzess Clinical Trials
See Literature
Linzess Note
Not Applicable
Linzess Patient Counseling
See Literature
Linzess Generic Name & Formulations
Legal Class
Rx
General Description
Linaclotide 72mcg, 145mcg, 290mcg; caps.
Pharmacological Class
Guanylate cyclase-C agonist.
How Supplied
Caps—30
Manufacturer
Generic Availability
NO
Linzess Indications
Indications
Chronic idiopathic constipation (CIC).
Linzess Dosage and Administration
Adult
Swallow whole. Take on empty stomach, at least 30mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. 145mcg once daily. A dosage of 72mcg once daily may be used based on individual presentation or tolerability.
Children
<2yrs: contraindicated. 2–<18yrs: not established.
Linzess Contraindications
Contraindications
Children <2yrs old. Known or suspected mechanical GI obstruction.
Linzess Boxed Warnings
Boxed Warning
Risk of serious dehydration in pediatric patients <2yrs of age.
Linzess Warnings/Precautions
Warnings/Precautions
Consider dose suspension and rehydration if severe diarrhea occurs. Pregnancy. Nursing mothers.
Linzess Pharmacokinetics
Elimination
Fecal.
Linzess Interactions
Linzess Adverse Reactions
Adverse Reactions
Diarrhea, abdominal pain, flatulence, abdominal distention.
Linzess Clinical Trials
See Literature
Linzess Note
Not Applicable
Linzess Patient Counseling
See Literature
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