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Lialda Generic Name & Formulations
Legal Class
Rx
General Description
Mesalamine 1.2g; del-rel tabs.
Pharmacological Class
Aminosalicylate.
How Supplied
Tabs—120
Manufacturer
Generic Availability
YES
Lialda Indications
Indications
For induction and maintenance of remission in adults with mildly to moderately active ulcerative colitis. To treat mildly to moderately active ulcerative colitis in pediatric patients weighing ≥24kg.
Lialda Dosage and Administration
Adult
Swallow whole with food. Induction: 2.4–4.8g once daily. Maintenance: 2.4g once daily.
Children
<24kg: not established. Swallow whole with food. Take once daily. 24–35kg (Weeks 0 to 8): 2.4g; (after Week 8): 1.2g. >35–50kg (Weeks 0 to 8): 3.6g; (after Week 8): 2.4g. >50kg (Weeks 0 to 8): 4.8g; (after Week 8): 2.4g.
Lialda Contraindications
Not Applicable
Lialda Boxed Warnings
Not Applicable
Lialda Warnings/Precautions
Warnings/Precautions
Sulfasalazine allergy. Upper GI tract obstruction (eg, pyloric stenosis) may delay onset of action. Discontinue if acute intolerance syndrome is suspected. Discontinue at the 1st signs/symptoms of severe cutaneous adverse reactions. Conditions predisposing to myocarditis or pericarditis. Atopic dermatitis or eczema: may have more severe photosensitivity reactions. Nephrolithiasis. Ensure adequate hydration. Renal or hepatic impairment. History of renal disease. Assess renal function prior to and periodically during therapy. Discontinue if renal function deteriorates while on therapy. Elderly (monitor CBCs, platelets). Pregnancy. Nursing mothers: monitor infants.
Lialda Pharmacokinetics
Elimination
Renal.
Lialda Interactions
Interactions
Increased toxicity with nephrotoxic drugs (eg, NSAIDs). Increased risk for blood disorders, bone marrow failure, and associated complications with azathioprine or 6-mercaptopurine and/or other drugs known to cause myelotoxicity. May cause elevated test results when measuring urinary normetanephrine.
Lialda Adverse Reactions
Adverse Reactions
Headache, flatulence, abnormal LFTs, abdominal pain, diarrhea; children also: upper RTI, vomiting, anemia, viral infection; acute intolerance syndrome (cramping, bloody diarrhea, fever, headache, rash), renal impairment, hypersensitivity reactions, severe cutaneous adverse reactions (eg, SJS, TEN, DRESS, AGEP); rare: pancreatitis.
Lialda Clinical Trials
See Literature
Lialda Note
Not Applicable
Lialda Patient Counseling
See Literature
