Leuprolide Acetate Generic Name & Formulations
Leuprolide acetate 1mg/0.2mL; soln for SC inj; contains benzyl alcohol.
Mechanism of Action
Leuprolide acetate, a gonadotropin releasing hormone (GnRH) agonist, acts as a potent inhibitor of gonadotropin secretion when given continuously in therapeutic doses. Animal and human studies indicate that after an initial stimulation, chronic administration of leuprolide acetate results in suppression of testicular and ovarian steroidogenesis. This effect is reversible upon discontinuation of drug therapy.
Leuprolide Acetate Indications
Palliative treatment of advanced prostatic carcinoma.
Leuprolide Acetate Dosage and Administration
1mg SC daily. Rotate inj site.
Leuprolide Acetate Contraindications
Women. Pregnancy (Cat.X).
Leuprolide Acetate Boxed Warnings
Leuprolide Acetate Warnings/Precautions
Metastatic vertebral lesions. Urinary obstruction. Monitor serum testosterone, PSA, acid phosphatase. Increased risk of diabetes, MI, sudden cardiac death, stroke; monitor blood glucose, HbA1c, and for signs/symptoms of CVD during therapy. Risk of QT prolongation: long-term androgen deprivation therapy, congenital long QT syndrome, electrolyte abnormalities, or CHF, and concomitant Class IA or III antiarrhythmics. Instruct patient on correct self administration.
Leuprolide Acetate Pharmacokinetics
Half-life: ~3 hours.
Leuprolide Acetate Interactions
Concomitant Class IA (eg, quinidine, procainamide) or Class III (eg, amiodarone, sotalol) antiarrhythmics may prolong the QT interval.
Leuprolide Acetate Adverse Reactions
Hot flashes/sweats, inj site reaction, initial worsening of signs/symptoms (eg, bone pain, urinary tract obstruction, hematuria), edema, GI upset, pain, cardiovascular events, CNS and antiandrogenic effects, asthenia, spinal cord compression; hyperglycemia, anaphylactoid, photosensitivity.
Leuprolide Acetate Clinical Trials
Leuprolide Acetate Note
Leuprolide Acetate Patient Counseling