• Inborn errors of metabolism

Lamzede Generic Name & Formulations

General Description

Velmanase alfa-tycv 10mg; per vial; lyophilized pwd for IV infusion after reconstitution; preservative-free.

Pharmacological Class

Recombinant human lysosomal alpha-mannosidase.

How Supplied

Single-dose vials—1, 5, 10


Generic Availability


Mechanism of Action

Alpha-mannosidase catalyzes the degradation of accumulated mannose-containing oligosaccharides. The deficiency of alpha-mannosidase causes an intra-lysosomal accumulation of mannose-rich oligosaccharides in various tissues. Velmanase alfa-tycv provides an exogenous source of alpha-mannosidase. Velmanase alfa-tycv is internalized via binding to the mannose-6-phosphate receptor on the cell surface and transported into lysosomes where it is thought to exert enzyme activity.

Lamzede Indications


Non-central nervous system manifestations of alpha-mannosidosis.

Lamzede Dosage and Administration

Adults and Children

Consider pretreatment with antihistamines, antipyretics, and/or corticosteroids. ≤49kg: Give as IV infusion over ≥60mins. ≥50kg: max infusion rate of 25mL/hr. 1mg/kg once weekly; flush line with NaCl 0.9% inj. Dosage modifications due to hypersensitivity and/or infusion-related reactions: see full labeling. 

Lamzede Contraindications

Not Applicable

Lamzede Boxed Warnings

Boxed Warning

Severe hypersensitivity reactions.

Lamzede Warnings/Precautions


Have cardiopulmonary resuscitation equipment readily available. Discontinue immediately and treat if severe hypersensitivity or infusion-associated reaction (eg, anaphylaxis) occurs; consider withholding dose for 15–30mins or slowing rate (25–50%) if mild to moderate reaction occurs. Embryo-fetal toxicity. Advise females of reproductive potential to use effective contraception during and for 14 days after the last dose. Pregnancy: exclude status prior to initiation. Nursing mothers. 

Lamzede Pharmacokinetics


Catabolic pathways.


Half-life: 33.6 hours (in those with alpha-mannosidosis).

Lamzede Interactions

Not Applicable

Lamzede Adverse Reactions

Adverse Reactions

Hypersensitivity reactions, anaphylaxis, infusion-associated reactions,  nasopharyngitis, pyrexia, headache, arthralgia.

Lamzede Clinical Trials

See Literature

Lamzede Note

Not Applicable

Lamzede Patient Counseling

See Literature