Lactulose Solution

  • Hepatic encephalopathy

Lactulose Solution Generic Name & Formulations

General Description

Lactulose 10g/15mL; soln; for oral or rectal administration.

Pharmacological Class

Colonic acidifier.

How Supplied

Contact supplier.

Lactulose Solution Indications


Prevention and treatment of portal-systemic encephalopathy, including the stages of hepatic pre-coma and coma.

Lactulose Solution Dosage and Administration


Oral: 30–45mL 3–4 times daily; may adjust dose every day or two to produce 2–3 soft stools daily. Hourly doses of 30–45mL may be used to induce rapid laxation initially; when laxative effect has been achieved, reduce dose to recommended daily dose. Maintenance: continue recommended daily dose. Rectal: may be given as a retention enema via a rectal balloon catheter. Mix 300mL of lactulose solution with 700mL of water or physologic saline, retain for 30–60 minutes. May repeat every 4–6 hours; if evacuated too promptly, may be repeated immediately. Start oral route before stopping enema entirely.


Oral: Individualize dose to produce 2–3 soft stools daily. Infants: initially 2.5–10mL in divided doses. Older children and adolescents: 40–90mL/daily. If initial dose causes diarrhea, reduce dose immediately; discontinue if diarrhea persists.

Lactulose Solution Contraindications


Patients who require a low galactose diet.

Lactulose Solution Boxed Warnings

Not Applicable

Lactulose Solution Warnings/Precautions


Perform thorough bowel cleansing with non-fermentable solution prior to electrocautery procedures during proctoscopy or colonoscopy. Diabetes. Pregnancy (Cat.B). Nursing mothers.

Lactulose Solution Pharmacokinetics

See Literature

Lactulose Solution Interactions


Avoid concomitant laxatives. Caution with concomitant oral anti-infectives (eg, neomycin); monitor closely. May be antagonized by non-absorbable antacids.

Lactulose Solution Adverse Reactions

Adverse Reactions

Gas, cramping, diarrhea, nausea, vomiting; infants: also hyponatremia, dehydration.

Lactulose Solution Clinical Trials

See Literature

Lactulose Solution Note


Formerly known under the brand names Cephulac, Chronulac, Evalose.

Lactulose Solution Patient Counseling

See Literature