• Poisoning/overdose

Kloxxado Generic Name & Formulations

General Description

Naloxone HCl 8mg; per spray.

Pharmacological Class

Opioid antagonist.

How Supplied

Single-dose nasal spray—2


Generic Availability


Kloxxado Indications


Reversal of known or suspected opioid overdose, including respiratory and/or CNS depression.

Limitations of Use

Not a substitute for emergency medical care.

Kloxxado Dosage and Administration

Adults and Children

Give as single spray intranasally into one nostril. May give additional doses (using a new nasal spray) every 2–3mins in alternate nostrils if unresponsive or relapses into respiratory depression. Seek immediate emergency medical assistance after the first dose.

Kloxxado Contraindications

Not Applicable

Kloxxado Boxed Warnings

Not Applicable

Kloxxado Warnings/Precautions


Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in pre-existing cardiac disease. Have other resuscitative measures available. Elderly. Pregnancy; monitor for neonatal withdrawal symptoms. Nursing mothers.

Kloxxado Pharmacokinetics

See Literature

Kloxxado Interactions


Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.

Kloxxado Adverse Reactions

Adverse Reactions

Abdominal pain, asthenia, dizziness, headache, nasal discomfort, presyncope; opioid withdrawal.

Kloxxado Clinical Trials

See Literature

Kloxxado Note

Not Applicable

Kloxxado Patient Counseling

See Literature