Kinrix

— THERAPEUTIC DISORDERS TREATED —
  • Vaccines

Kinrix Generic Name & Formulations

General Description

Diphtheria and tetanus toxoids, acellular pertussis vaccine, aluminum hydroxide adsorbed; inactivated polio vaccine; susp for IM inj; preservative-free; contains traces of formaldehyde, polysorbate 80, neomycin, polymixin B.

Pharmacological Class

DTaP + IPV.

How Supplied

Single-dose vials—10; Single-dose prefilled Tip-Lok syringes—5 (without needles)

Manufacturer

Kinrix Indications

Indications

Immunization against diphtheria, tetanus, pertussis, and polio: As the 5th dose in the DTaP immunization series and the 4th dose in the inactivated poliovirus vaccine (IPV) series in children 4–6 years of age (before 7th birthday) who previously received Infanrix (DTaP) and/or Pediarix (DTaP, HB, IPV) for the first 3 doses and Infanrix for the 4th dose.

Kinrix Dosage and Administration

Adult

Not applicable.

Children

<4yrs or ≥7yrs: not recommended. 4–6yrs: One dose of 0.5mL IM in deltoid muscle.

Kinrix Contraindications

Contraindications

Anaphylaxis associated with previous diphtheria, tetanus, pertussis, or polio vaccine. Encephalopathy within 7 days of previous pertussis vaccine. Progressive neurological disorders (eg, infantile spasms, uncontrolled epilepsy, progressive encephalopathy).

Kinrix Boxed Warnings

Not Applicable

Kinrix Warnings/Precautions

Warnings/Precautions

Guillain-Barre syndrome within 6 weeks of previous tetanus vaccination. Fever (≥105°F within 48hrs), persistent inconsolable crying (≥3hrs within 48hrs), shock (within 48hrs), or seizures (within 3 days) after previous pertussis vaccine: see literature. Seizure risk: may give antipyretics. Latex allergy (prefilled syringes). Have epinephrine available. Pregnancy (Cat.C): not applicable.

Kinrix Pharmacokinetics

See Literature

Kinrix Interactions

Interactions

May give with concomitant vaccines (eg, MMR). Immunosuppressants (eg, radiation, chemotherapy, high-dose steroids): may get suboptimal response.

Kinrix Adverse Reactions

Adverse Reactions

Inj site pain, redness, local swelling, increase in arm circumference, drowsiness, fever, loss of appetite.

Kinrix Clinical Trials

See Literature

Kinrix Note

Notes

Report adverse events to VAERS at (800) 822-7967 and to GlaxoSmithKline at (888) 825-5249.

Kinrix Patient Counseling

See Literature

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