Kimmtrak

Risk of life-threatening cytokine release syndrome (CRS). Withhold or discontinue therapy based on persistence and severity of CRS. Have medications and resuscitative equipment readily available. Ensure patients are euvolemic prior to initiation. Administer first 3 infusions in appropriate healthcare setting; monitor during and for at least 16hrs after infusions. If Grade ≥2 hypotension (requiring medical intervention) does not occur during or after the 3^rd infusion, give subsequent doses in an ambulatory care setting; monitor for at least 30mins after each infusion. Monitor fluid status, vital signs, oxygenation levels. Monitor for skin reactions; treat with antihistamine, topical or systemic steroids if occur. Monitor ALT, AST, and total bilirubin prior to and during treatment. Embryo-fetal toxicity. Advise females of reproductive potential to use effective contraception during and for 1 week after the last dose. Pregnancy: exclude status prior to initiation. Nursing mothers: not recommended (during and for at least 1 week after the last dose).