Kedrab Generic Name & Formulations
Legal Class
Rx
General Description
Rabies immune globulin (human) 150 IU/mL; soln for IM inj; preservative-free.
Pharmacological Class
Immune globulin.
How Supplied
Single-use vial (2mL, 10mL)—1
Manufacturer
Generic Availability
NO
Kedrab Indications
Indications
Post-exposure prophylaxis of rabies infection, to be given with a full course of rabies vaccine.
Kedrab Dosage and Administration
Adult
Prior to administration, follow recommendations for local treatment of wounds. Administer as soon as possible after exposure; may give up to 7 days after first vaccine dose. 20 IU/kg as single dose with first dose of rabies vaccine. If feasible, infiltrate dose into and around the wound; inj remainder into upper arm deltoid region. Avoid same inj site as rabies vaccine or repeat doses of Kedrab once vaccine treatment is initiated.
Children
See full labeling.
Kedrab Contraindications
Not Applicable
Kedrab Boxed Warnings
Not Applicable
Kedrab Warnings/Precautions
Warnings/Precautions
Do not inj into gluteal region or blood vessel. History of complete pre- or post-exposure vaccination and confirmed adequate rabies titer: not recommended. Discontinue if allergic or anaphylactic reaction occurs; have epinephrine available. History of allergic reactions to human immunoglobulins; monitor. IgA deficiency. Increased risk of thrombosis with acquired or hereditary hypercoagulable states, prolonged immobilization, in-dwelling vascular catheters, older age, estrogen use, a history of venous or arterial thrombosis, cardiovascular risk factors, hyperviscosity syndromes; monitor for ≥24hrs post-injection. Increased risk of hemolysis with non-O blood group types, underlying inflammatory conditions, high cumulative doses of immune globulins. Contains human plasma; monitor for possible viral disease and variant Creutzfeldt-Jakob disease transmission. Pregnancy. Nursing mothers.
Kedrab Pharmacokinetics
See Literature
Kedrab Interactions
Interactions
Avoid measles vaccine within 4 months of Kedrab; avoid other live attenuated vaccines within 3 months. May interfere with serologic tests (eg, Coombs’ test).
Kedrab Adverse Reactions
Adverse Reactions
Inj site pain, headache, muscle pain, upper respiratory tract infection; anaphylactic shock.
Kedrab Clinical Trials
See Literature
Kedrab Note
Not Applicable
Kedrab Patient Counseling
See Literature
Images
