• ADHD

Kapvay Generic Name & Formulations

General Description

Clonidine HCl 0.1mg; extended-release tablets.

Pharmacological Class

Central alpha-2 agonist.

How Supplied

Ext-rel tabs—60

Kapvay Indications


Attention deficit hyperactivity disorder (ADHD), as monotherapy or as an adjunct to stimulant medications.

Kapvay Dosage and Administration


Not recommended.


<6yrs: not recommended. Swallow whole. Individualize. Titrate by response. Initially 0.1mg at bedtime for 1 week, then 0.1mg twice daily for 1 week, then 0.1mg in the morning and 0.2mg at bedtime for 1 week, then 0.2mg twice daily. Withdraw gradually; reduce by 0.1mg/day at 3–7 day intervals.

Kapvay Contraindications

Not Applicable

Kapvay Boxed Warnings

Not Applicable

Kapvay Warnings/Precautions


Do not substitute with other clonidine products on a mg-per-mg basis. Monitor heart rate and BP prior to initiation, after dose increases, and periodically during therapy. Hypotension, bradycardia, heart block, vascular disease, cardio- or cerebrovascular disease, chronic renal failure, cardiac conduction abnormalities: titrate slowly and monitor. History of, or conditions that predispose to syncope. Dehydration. Elevated temperature. Avoid abrupt discontinuation to minimize risk of rebound hypertension. Renal impairment. Pregnancy. Nursing mothers: monitor infants.

Kapvay Pharmacokinetics

See Literature

Kapvay Interactions


Potentiated by alcohol, other CNS depressants (eg, benzodiazepines, antipsychotics, barbiturates); avoid. Potentiates AV block, bradycardia with drugs that affect sinus node function or AV node conduction (eg, digitalis, calcium channel blockers, β-blockers); avoid. Additive effects with antihypertensives; monitor. Hypotensive effects may be antagonized by tricyclic antidepressants; monitor. May need to adjust dose of concurrent stimulant medication.

Kapvay Adverse Reactions

Adverse Reactions

Somnolence, fatigue, irritability, insomnia, nightmares, constipation, dry mouth, decreased appetite, dizziness; bradycardia, allergic reactions.

Kapvay Clinical Trials

See Literature

Kapvay Note

Not Applicable

Kapvay Patient Counseling

See Literature