Kanuma Generic Name & Formulations
Sebelipase alfa 20mg/10mL; soln for IV infusion after dilution; preservative-free.
Hydrolytic lysosomal cholesteryl ester and triacylglycerol-specific enzyme.
Lysosomal acid lipase (LAL) deficiency.
Kanuma Dosage and Administration
Adults and Children
<1 month: not established. Give as IV infusion over ≥2hrs; consider further prolonging infusion time for doses >1mg/kg or if hypersensitivity reactions occur. May consider a 1hr infusion for the 1mg/kg dose in those who tolerate the infusion. ≥1 month: 1mg/kg once every other week; increase to 3mg/kg once every other week if suboptimal response. Infants with rapidly progressive deficiency within first 6 months of life: initially 1mg/kg once weekly; increase to 3mg/kg once weekly if suboptimal response; may further increase to 5mg/kg once weekly if continued suboptimal response. May pre-treat with antipyretics and/or antihistamines.
Kanuma Boxed Warnings
Monitor for hypersensitivity reactions during and after infusion; interrupt or lower infusion rate based on severity. Discontinue immediately and treat if severe hypersensitivity including anaphylaxis occurs. Eggs or egg products allergy. Pregnancy. Nursing mothers.
Kanuma Adverse Reactions
Diarrhea, vomiting, fever, rhinitis, anemia, cough, nasopharyngitis, urticaria, headache, oropharyngeal pain, asthenia, constipation, nausea.
Kanuma Clinical Trials
Kanuma Patient Counseling