Jardiance Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Jardiance Indications
Indications
To reduce the risk of cardiovascular death and hospitalization for heart failure (HF) in adults with HF. To reduce the risk of cardiovascular (CV) death in adults with T2DM and established CV disease.
Jardiance Dosage and Administration
Adult
Take in the AM. 10mg once daily. Insufficient data for dosing: in those who have T2DM and established CV disease (with eGFR <30mL/min/1.73m2), or those who have HF (with eGFR <20mL/min/1.73m2).
Children
Not established.
Jardiance Contraindications
Contraindications
Jardiance Boxed Warnings
Not Applicable
Jardiance Warnings/Precautions
Warnings/Precautions
Jardiance Pharmacokinetics
Absorption
- Peak plasma concentration is reached at 1.5 hours post-dose.
Distribution
-
Apparent steady-state volume of distribution: ~73.8 L.
-
Plasma protein bound: 86.2%.
Elimination
- Renal (54.4%), fecal (41.2%). Half-life: 12.4 hours.
Jardiance Interactions
Interactions
Greater potential for volume depletion with concomitant diuretics. Consider a lower dose of concomitant insulin or insulin secretagogue (eg, sulfonylurea) to reduce risk of hypoglycemia. May antagonize serum lithium concentrations; monitor levels more frequently. May result in false (+) urine glucose tests or unreliable measurements of 1,5-AG assay; use alternative methods to monitor glycemic control.
Jardiance Adverse Reactions
Adverse Reactions
Jardiance Clinical Trials
See Literature
Jardiance Note
Not Applicable
Jardiance Patient Counseling
See Literature
Jardiance Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Jardiance Indications
Indications
Adjunct to diet and exercise to improve glycemic control in adults and pediatric patients ≥10yrs with type 2 diabetes mellitus (T2DM).
Limitations of Use
Jardiance Dosage and Administration
Adults and Children
<10yrs: not established. Take in the AM. ≥10yrs: Initially 10mg once daily; may increase to 25mg, if tolerated.
Jardiance Contraindications
Contraindications
Jardiance Boxed Warnings
Not Applicable
Jardiance Warnings/Precautions
Warnings/Precautions
Jardiance Pharmacokinetics
Absorption
- Peak plasma concentration is reached at 1.5 hours post-dose.
Distribution
-
Apparent steady-state volume of distribution: ~73.8 L.
-
Plasma protein bound: 86.2%.
Elimination
- Renal (54.4%), fecal (41.2%). Half-life: 12.4 hours.
Jardiance Interactions
Interactions
Greater potential for volume depletion with concomitant diuretics. Consider a lower dose of concomitant insulin or insulin secretagogue (eg, sulfonylurea) to reduce risk of hypoglycemia. May antagonize serum lithium concentrations; monitor levels more frequently. May result in false (+) urine glucose tests or unreliable measurements of 1,5-AG assay; use alternative methods to monitor glycemic control.
Jardiance Adverse Reactions
Adverse Reactions
Jardiance Clinical Trials
See Literature
Jardiance Note
Not Applicable
Jardiance Patient Counseling
See Literature
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