• Benign prostatic hyperplasia/urinary retention

Jalyn Generic Name & Formulations

General Description

Dutasteride 0.5mg, tamsulosin HCl 0.4mg; caps.

Pharmacological Class

Type I and II 5 alpha-reductase inhibitor + alpha-1A blocker.

How Supplied

Caps—30, 90


Jalyn Indications


Benign prostatic hyperplasia (BPH).

Limitations of Use

Not approved for preventing prostate cancer.

Jalyn Dosage and Administration


Swallow whole. Take 1 cap daily approx. 30mins after the same meal each day.


Not established.

Jalyn Contraindications


Pregnancy. Nursing mothers.

Jalyn Boxed Warnings

Not Applicable

Jalyn Warnings/Precautions


Increased risk of high-grade prostate cancer. Monitor prostate specific antigen (PSA) values (set new baseline PSA after 3–6 months of treatment); double PSA levels to compare with normal values. Rule out prostate cancer and other urological disorders prior to treatment. Syncope. End-stage renal disease. Severe hepatic impairment. Cataract and glaucoma surgery (intraoperative floppy iris syndrome possible); do not initiate tamsulosin-containing products. Poor metabolizers (low CYP2D6 activity). Sulfa allergy. Avoid donating blood until at least 6 months after last dose. Pregnant women and those of childbearing potential should avoid handling caps.

Jalyn Pharmacokinetics

See Literature

Jalyn Interactions


Concomitant strong CYP3A4 inhibitors (eg, ketoconazole): not recommended. Caution with moderate CYP3A4 inhibitors (eg, erythromycin), strong (eg, paroxetine) or moderate (eg, terbinafine) CYP2D6 inhibitors, or a combination of both CYP3A4 and CYP2D6 inhibitors. Do not use with other alpha-blockers. Potentiated by cimetidine. Dutasteride may be potentiated by CYP3A4/5 inhibitors (eg, ritonavir, diltiazem, verapamil, erythromycin). Caution with PDE-5 inhibitors (may increase orthostatic hypotension). Monitor warfarin.

Jalyn Adverse Reactions

Adverse Reactions

Ejaculation disorders, impotence, decreased libido, dizziness, breast disorders, orthostatic hypotension and/or syncope; rare: priapism.

Jalyn Clinical Trials

See Literature

Jalyn Note

Not Applicable

Jalyn Patient Counseling

See Literature