Isovue-m 300 Generic Name & Formulations
Iopamidol 612mg/mL; soln for intrathecal administration; contains sodium 0.043mg, organically bound iodine 300mg per mL.
ISOVUE-M 200: Single dose vials (10mL, 20mL)—10; ISOVUE-M 300: Single dose vials (15mL)—10
Isovue-m 300 Indications
For intrathecal administration in adult neuroradiology inculding myelography (lumbar, thoracic, cervical, total columnar), and for contrast enhancement of computed tomographic (CECT) cisternography and ventriculography.
Isovue-m 300 Dosage and Administration
Adults and Children
See full labeling regarding dosing based on procedure.
Isovue-m 300 Contraindications
Concomitant corticosteroids. Repeat myelography in the event of technical failure. Significant local or systemic infections where bacteremia is likely.
Isovue-m 300 Boxed Warnings
Isovue-m 300 Warnings/Precautions
Should be administered by professional trained in use of radiopaque agents in appropriate facilities with emergency treatment readily available. Increased intracranial pressure. Intracranial tumor. Abscess. Hematoma. History of convulsive disorder. Severe cardiovascular disease. Chronic alcoholism. Multiple sclerosis. Homozygous sickle cell disease. Multiple myeloma. Pheochromocytoma. Hyperthyroidism. Thyroid dysfunction (esp. children 0–3yrs); monitor. Diabetes. Patients with evidence of inadvertant intracranial entry of large or concentrated bolus of contrast medium: increased risk of seizures; consider prophylactic diazepam or barbiturate therapy. Direct intracisternal or ventricular administration for standard radiography: not recommended. Maintain elevation of head during procedure, on the stretcher, or in bed. Avoid excessive and active patient movement or straining. Maintain adequate hydration. Elderly. Pregnancy. Nursing mothers.
Isovue-m 300 Pharmacokinetics
Isovue-m 300 Interactions
Concomitant drugs that lower seizure threshold (eg, phenothiazines, MAOIs, tricyclics, CNS stimulants, analeptics, major tranquilizers, antipsychotics): not recommended; discontinue 48hrs and for at least 24hrs post-procedure. May reduce iodine-binding capacity of thyroid tissue for up to 2 weeks.
Isovue-m 300 Adverse Reactions
Headache, GI upset, back pain, leg pain, neck pain, hypotension, others.
Isovue-m 300 Clinical Trials
Isovue-m 300 Note
Isovue-m 300 Patient Counseling