Indications for Isosorbide dinitrate:
Prophylaxis and treatment (in patients that do not respond to sublingual nitroglycerin) of angina.
2.5–5mg sublingually 15 mins before activity; allow a daily dose-free interval of at least 14hrs.
Isosorbide dinitrate Contraindications:
Concomitant PDEIs (eg, sildenafil, tadalafil, vardenafil), riociguat.
Isosorbide dinitrate Warnings/Precautions:
Recent MI. CHF. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Tolerance may develop. Elderly. Pregnancy (Cat.C). Nursing mothers.
Isosorbide dinitrate Classification:
Isosorbide dinitrate Interactions:
See Contraindications. Severe hypotension with sildenafil. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers.
Headache, orthostatic hypotension, paradoxical bradycardia.
Sublingual tabs formerly known under the brand names Isordil, Sorbitrate.
Generic Drug Availability:
Sublingual—contact supplier; Titradose—100