Indications for: Isosorbide dinitrate

Prophylaxis and treatment (in patients that do not respond to sublingual nitroglycerin) of angina.

Adult Dosage:

2.5–5mg sublingually 15 mins before activity; allow a daily dose-free interval of at least 14hrs.

Children Dosage:

Not established.

Isosorbide dinitrate Contraindications:

Concomitant PDEIs (eg, sildenafil, tadalafil, vardenafil), riociguat.

Isosorbide dinitrate Warnings/Precautions:

Recent MI. CHF. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Tolerance may develop. Elderly. Pregnancy (Cat.C). Nursing mothers.

See Also:

Isosorbide dinitrate Classification:


Isosorbide dinitrate Interactions:

See Contraindications. Severe hypotension with sildenafil. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers.

Adverse Reactions:

Headache, orthostatic hypotension, paradoxical bradycardia.


Sublingual tabs formerly known under the brand names Isordil, Sorbitrate.

Generic Drug Availability:

Titradose (YES)

How Supplied:

Sublingual—contact supplier; Titradose—100

Pricing for Isosorbide dinitrate

20mg tablet (Qty: 90)
Appx. price $35