Angina:
Indications for Isosorbide dinitrate:
Prophylaxis and treatment (in patients that do not respond to sublingual nitroglycerin) of angina.
Adult:
2.5–5mg sublingually 15 mins before activity; allow a daily dose-free interval of at least 14hrs.
Children:
Not established.
Contraindications:
Concomitant PDEIs (eg, sildenafil, tadalafil, vardenafil), riociguat.
Warnings/Precautions:
Recent MI. CHF. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Tolerance may develop. Elderly. Pregnancy (Cat.C). Nursing mothers.
See Also:
Pharmacologic Class:
Nitrate.
Interactions:
See Contraindications. Severe hypotension with sildenafil. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers.
Adverse Reactions:
Headache, orthostatic hypotension, paradoxical bradycardia.
Note:
Sublingual tabs formerly known under the brand names Isordil, Sorbitrate.
Generic Availability:
Titradose (YES)
How Supplied:
Sublingual—contact supplier; Titradose—100
