Indications for Ipratropium Bromide + Albuterol Sulfate:

COPD when a second aerosol bronchodilator is needed.


≥18yrs: 1 vial by nebulizer 4–6 times daily.


<18yrs: not recommended.


Atropine allergy.


Not for primary treatment of acute attack. Avoid excessive use. Discontinue if paradoxical bronchospasm or cardiovascular effects occur. Cardiovascular disease (eg, coronary insufficiency, arrhythmias, hypertension). Hyperthyroidism. Diabetes. Seizure disorders. Narrow angle glaucoma. GI or GU obstruction. Hepatic or renal disease. Avoid eyes. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.

Pharmacologic Class:

Anticholinergic + beta-2 agonist.


Avoid MAOIs, tricyclics within 14 days (increased cardiovascular effects). Caution with other anticholinergics, sympathomimetics, drugs that lower potassium. Monitor digoxin. Antagonized by β-blockers.

Adverse Reactions:

Lung disorders, pharyngitis, chest pain, GI disturbances, bronchitis, UTI, leg cramps, pain, voice changes, anticholinergic effects, nervousness, headache, dizziness, insomnia, tachycardia, hypokalemia, paradoxical bronchospasm.


Formerly known under the brand name DuoNeb.

How Supplied:

Contact supplier.