Indications for IOPIDINE 1%:

To control or prevent post-surgical elevations in IOP after argon laser trabeculoplasty or iridotomy, or Nd:YAG posterior capsulotomy.


Instill 1 drop into operative eye 1hr before laser surgery and a second drop immediately after procedure is completed.


Not established.


Clonidine allergy. Concomitant MAOIs.


Monitor visual fields. Severe uncontrolled cardiovascular disease, hypertension, coronary insufficiency. Recent myocardial infarction. Cerebrovascular disease. Raynaud's disease. Thromboangiitis obliterans. History of vasovagal attack. Discontinue if ocular allergic-like reactions occur. Renal or hepatic impairment: closely monitor cardiovascular parameters. Depression. May mask hypoglycemia. Pregnancy. Nursing mothers (1% soln: discontinue nursing temporarily for 1 day of use).

See Also:

Pharmacologic Class:

Alpha-2 agonist.


See Contraindications. May potentiate CNS depressants (eg, alcohol, barbiturates, opiates, sedatives, anesthetics). Caution with TCAs, β-blockers, antihypertensives, cardiac glycosides, others (eg, clonidine). Concomitant CV drugs: monitor HR, BP periodically.

Adverse Reactions:

Hyperemia, pruritus, dry mouth, itching, discomfort, tearing, dizziness, solmnolence, lid edema, blurred vision, foreign body sensation, dry eye, conjunctivitis, discharge, blanching; tachyphylaxis may develop after 1 month; also in post-laser surgery: upper lid elevation, inflammation, nasal decongestion, mydriasis, irregular HR.

How Supplied:

Soln 0.5%—contact supplier; 1% (0.1mL)—2