Iopidine 1%

  • Glaucoma

Iopidine 1% Generic Name & Formulations

General Description

Apraclonidine (as HCl) 1%; oph soln; contains benzalkonium chloride.

Pharmacological Class

Alpha-2 agonist.

How Supplied

Soln 0.5%—contact supplier; 1% (0.1mL)—2

Iopidine 1% Indications


To control or prevent post-surgical elevations in IOP after argon laser trabeculoplasty or iridotomy, or Nd:YAG posterior capsulotomy.

Iopidine 1% Dosage and Administration


Instill 1 drop into operative eye 1hr before laser surgery and a second drop immediately after procedure is completed.


Not established.

Iopidine 1% Contraindications


Clonidine allergy. Concomitant MAOIs.

Iopidine 1% Boxed Warnings

Not Applicable

Iopidine 1% Warnings/Precautions


Monitor visual fields. Severe uncontrolled cardiovascular disease, hypertension, coronary insufficiency. Recent myocardial infarction. Cerebrovascular disease. Raynaud's disease. Thromboangiitis obliterans. History of vasovagal attack. Discontinue if ocular allergic-like reactions occur. Renal or hepatic impairment: closely monitor cardiovascular parameters. Depression. May mask hypoglycemia. Pregnancy. Nursing mothers (1% soln: discontinue nursing temporarily for 1 day of use).

Iopidine 1% Pharmacokinetics

See Literature

Iopidine 1% Interactions


See Contraindications. May potentiate CNS depressants (eg, alcohol, barbiturates, opiates, sedatives, anesthetics). Caution with TCAs, β-blockers, antihypertensives, cardiac glycosides, others (eg, clonidine). Concomitant CV drugs: monitor HR, BP periodically.

Iopidine 1% Adverse Reactions

Adverse Reactions

Hyperemia, pruritus, dry mouth, itching, discomfort, tearing, dizziness, solmnolence, lid edema, blurred vision, foreign body sensation, dry eye, conjunctivitis, discharge, blanching; tachyphylaxis may develop after 1 month; also in post-laser surgery: upper lid elevation, inflammation, nasal decongestion, mydriasis, irregular HR.

Iopidine 1% Clinical Trials

See Literature

Iopidine 1% Note

Not Applicable

Iopidine 1% Patient Counseling

See Literature