• ADHD

Intuniv Generic Name & Formulations

General Description

Guanfacine (as HCl) 1mg, 2mg, 3mg, 4mg; ext-rel tabs.

Pharmacological Class

Central alpha-2A agonist.

How Supplied


Generic Availability


Intuniv Indications


Attention deficit hyperactivity disorder (ADHD), as monotherapy or as an adjunct to stimulant medications.

Intuniv Dosage and Administration


≥18yrs: not established.


Swallow whole with water, milk, or other liquid. Do not give with high-fat meals. <6yrs: not established. 6–17yrs: Initially 1mg once daily; adjust in increments of no more than 1mg/week; target range: 0.05–0.12mg/kg/day (1–7mg/day). Doses >4mg/day: not evaluated in children (6–12yrs); doses >7mg/day: not evaluated in adolescents (13–17yrs). Reevaluate periodically. Withdraw gradually (by 1mg every 3–7 days). Dose adjustment with concomitant strong and moderate CYP3A4 inhibitors or inducers: see full labeling.

Intuniv Contraindications


Concomitant use with other forms of guanfacine.

Intuniv Boxed Warnings

Not Applicable

Intuniv Warnings/Precautions


Do not substitute with other forms of guanfacine on a mg-mg basis. Concomitant antihypertensives, other risks for hypotension, syncope, bradycardia, heart block, cardiovascular or cerebrovascular disease. Monitor heart rate and BP prior to initiation, after dose increases, and periodically during therapy. Dehydration. Elevated temperature. Cardiac conduction abnormalities. Avoid abrupt discontinuation to minimize risk of rebound hypertension. Renal or hepatic impairment. Pregnancy. Nursing mothers: monitor infants.

Intuniv Pharmacokinetics

See Literature

Intuniv Interactions


Avoid with alcohol. May be potentiated by strong and moderate CYP3A4 inhibitors (eg, ketoconazole, fluconazole). May be antagonized by strong and moderate CYP3A4 inducers (eg, carbamazepine, rifampin, efavirenz). Additive effects with other antihypertensives, CNS depressants (eg, benzodiazepines, antipsychotics, barbiturates). May worsen sinus node dysfunction and AV block when concomitant other sympatholytic drugs; monitor.

Intuniv Adverse Reactions

Adverse Reactions

Somnolence, sedation, fatigue, nausea, lethargy, hypotension, insomnia, dizziness, abdominal pain, dry mouth, vomiting, irritability, constipation; bradycardia, hypertensive encephalopathy.

Intuniv Clinical Trials

See Literature

Intuniv Note

Not Applicable

Intuniv Patient Counseling

See Literature