• Viral infections

Intelence Generic Name & Formulations

General Description

Etravirine 25mg+, 100mg, 200mg; tabs, (+) scored.

Pharmacological Class

Non-nucleoside reverse transcriptase inhibitor.

How Supplied

Tabs 25mg, 100mg—120; 200mg—60


Intelence Indications


HIV-1 infection, in combination with other antiretrovirals, in treatment-experienced patients ≥2yrs of age.

Intelence Dosage and Administration


Take after meals. Swallow whole with liquid; or, may disperse tabs in water and drink. ≥18yrs: 200mg twice daily.


Take after meals. Swallow whole with liquid; or, may disperse tabs in water and drink. <2yrs or <10kg: not recommended. ≥2yrs (≥10kg–<20kg): 100mg twice daily; (≥20kg–<25kg): 125mg twice daily; (≥25kg–<30kg): 150mg twice daily; (≥30kg): 200mg twice daily.

Intelence Contraindications

Not Applicable

Intelence Boxed Warnings

Not Applicable

Intelence Warnings/Precautions


Discontinue immediately if severe skin or hypersensitivity reactions develop; monitor closely. Monitor clinical status including liver transaminases. Severe hepatic impairment. Elderly. Pregnancy. Nursing mothers: not recommended.

Intelence Pharmacokinetics

See Literature

Intelence Interactions


Concomitant tipranivir/ritonavir, fosamprenavir/ritonavir, atazanavir/cobicistat, darunavir/cobicistat, PIs without ritonavir (eg, atazanavir, fosamprenavir, nelfinavir, indinavir), ritonavir (600mg twice daily), NNRTIs (eg, efavirenz, nevirapine, delavirdine, rilpivirine), anticonvulsants (eg, carbamazepine, phenobarbital, phenytoin), rifampin, rifapentine, St. John's wort, elbasvir/grazoprevir, simeprevir: not recommended. Antagonizes dolutegravir (should only be used with etravirine when concomitant with darunavir/ritonavir, lopinavir/ritonavir, or atazanavir/ritonavir). May affect, or be affected by, drugs that induce or inhibit, or that are substrates of, CYP3A4, CYP2C9, CYP2C19 (eg, azole antifungals, immunosuppressants); monitor. May antagonize antiarrhythmics (eg, amiodarone, bepridil, disopyramide, flecainide, lidocaine, mexiletine, propafenone, quinidine) (monitor), sildenafil, clopidogrel (consider alternatives), antimalarials (eg, artemether/lumefantrine). May be antagonized by systemic dexamethasone (consider alternatives). May potentiate diazepam. Clarithromycin (consider azithromycin for treating MAC). Adjust statin (except pravastatin, rosuvastatin), maraviroc, daclatasvir dose. Monitor digoxin, warfarin, buprenorphine, buprenorphine/naloxone, methadone. Rifabutin (adjust dose with etravirine monotherapy). See full labeling.

Intelence Adverse Reactions

Adverse Reactions

Severe skin reactions (may be fatal, eg, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme), hypersensitivity (eg, DRESS), peripheral neuropathy, diarrhea; fat redistribution, immune reconstitution syndrome.

Intelence Clinical Trials

See Literature

Intelence Note


Report pregnant patients exposed to etravirine by calling (800) 258-4263.

Intelence Patient Counseling

See Literature