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Innopran Xl Generic Name & Formulations
Legal Class
Rx
General Description
Propranolol HCl 80mg, 120mg; ext-rel caps.
Pharmacological Class
Noncardioselective beta-blocker.
How Supplied
Caps—30, 100
Manufacturer
Generic Availability
NO
Innopran Xl Indications
Indications
Hypertension.
Innopran Xl Dosage and Administration
Adult
≥18yrs: Take once daily at bedtime (10PM). Take consistently with regard to food. Initially 80mg/day, may increase to 120mg/day.
Children
<18yrs: not established.
Innopran Xl Contraindications
Contraindications
Cardiogenic shock. Sinus bradycardia, sick sinus syndrome and >1st -degree AV block unless paced. Asthma.
Innopran Xl Boxed Warnings
Not Applicable
Innopran Xl Warnings/Precautions
Warnings/Precautions
Risk of cardiac ischemia after abrupt discontinuation. Bronchospastic disease. Heart failure. Cardiogenic shock. Wolff-Parkinson-White syndrome. Diabetes. May mask signs of hypoglycemia, hyperthyroidism. Surgery. SLE. Musculoskeletal disease. Renal or hepatic impairment. Avoid abrupt cessation. Elderly. Neonates. Pregnancy. Nursing mothers.
Innopran Xl Pharmacokinetics
See Literature
Innopran Xl Interactions
Interactions
Potentiated by substrates or inhibitors of CYP2D6 (eg, amiodarone, cimetidine, fluoxetine, paroxetine, quinidine, ritonavir), CYP1A2 (eg, imipramine, ciprofloxacin, theophylline, zolmitriptan), or CYP2C19 (eg, fluconazole), CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, MAOIs, tricyclic antidepressants, alcohol. Antagonized by NSAIDs, aluminum hydroxide; bile acid resins (eg, cholestyramine, colestipol); smoking, chronic alcohol use, and other inducers of CYP2D6, 1A2, or 2C19. Potentiates amiodarone, chlorpromazine, diazepam, lidocaine, bupivacaine, mepivacaine, propafenone, theophylline, thioridazine, warfarin, rizatriptan, zolmitriptan. May increase cardiac effects of calcium channel blockers, digitalis, disopyramide, lidocaine. Bradycardia with catecholamine-depleting drugs. Increased orthostatic hypotension with α-blockers. Caution when withdrawing clonidine. Increased bronchial hyperreactivity with ACEIs. May interfere with glaucoma or thyroid tests. May block epinephrine.
Innopran Xl Adverse Reactions
Adverse Reactions
Fatigue, dizziness, constipation, bradycardia, heart failure/block, GI upset, bronchospasm, agranulocytosis, myopathy, myotonia, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria); rare: SLE, alopecia, impotence.
Innopran Xl Clinical Trials
See Literature
Innopran Xl Note
Not Applicable
Innopran Xl Patient Counseling
See Literature
