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Ingrezza Generic Name & Formulations
Legal Class
Rx
General Description
Valbenazine 40mg, 80mg; caps.
Pharmacological Class
Vesicular monoamine transporter 2 (VMAT2) inhibitor.
How Supplied
Caps 40mg—30, 90; 80mg—30; Initiation pack (4-week)—28 (7x40mg + 21x80mg)
Manufacturer
Generic Availability
NO
Ingrezza Indications
Indications
Tardive dyskinesia.
Ingrezza Dosage and Administration
Adult
Take with or without food. Initially 40mg once daily; increase to 80mg once daily after 1 week. For some patients, continuation of 40mg once daily may be considered. Moderate or severe hepatic impairment: 40mg once daily. Concomitant with strong CYP3A4 inducers: not recommended. Concomitant with strong CYP3A4 or CYP2D6 inhibitors, or CYP2D6 poor metabolizers: 40mg once daily.
Children
Not established.
Ingrezza Contraindications
Not Applicable
Ingrezza Boxed Warnings
Not Applicable
Ingrezza Warnings/Precautions
Warnings/Precautions
Somnolence. Avoid in congenital long QT syndrome or arrhythmias associated with a prolonged QT interval. Known CYP2D6 poor metabolizers. Parkinsonism: reduce dose or discontinue if significant signs/symptoms develop. Moderate or severe hepatic impairment: reduce dose (see Adults). Pregnancy. Nursing mothers: not recommended (during and for 5 days after final dose).
Ingrezza Pharmacokinetics
See Literature
Ingrezza Interactions
Interactions
See Adults. Avoid concomitant with MAOIs (eg, isocarboxazid, phenelzine, selegiline). Potentiated by strong CYP3A4 inhibitors (eg, itraconazole, ketoconazole, clarithromycin). May be potentiated by strong CYP2D6 inhibitors (eg, paroxetine, fluoxetine, quinidine). Antagonized by strong CYP3A4 inducers (eg, rifampin, carbamazepine, phenytoin, St. John's wort). Monitor digoxin levels; dose adjustment may be needed.
Ingrezza Adverse Reactions
Adverse Reactions
Somnolence, anticholinergic effects, balance disorders/fall, headache, akathisia, vomiting, nausea, arthralgia.
Ingrezza Clinical Trials
See Literature
Ingrezza Note
Not Applicable
Ingrezza Patient Counseling
See Literature
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