Anemias:
Indications for INFED:
Iron deficiency where oral therapy is unsatisfactory or impossible.
Adults and Children:
<4mos: not recommended. Give by IV or deep IM inj into upper outer quadrant of buttock only. Administer 0.5mL test dose first; if no signs/symptoms of anaphylactic-type reactions, may give full therapeutic dose. ≥4mos: Iron deficiency anemia: determine total dose based on hemoglobin and body weight (see full labeling). Iron replacement for blood loss: Replacement iron (in mg) = blood loss (in mL) × hematocrit. Max daily doses: <5kg: 0.5mL (25mg), <10kg: 1mL (50mg), ≥10kg: 2mL (100mg).
INFED Contraindications:
Anemias not associated with iron deficiency.
Boxed Warning:
Risk for anaphylactic-type reactions.
INFED Warnings/Precautions:
Monitor for signs/symptoms of anaphylactic-type reactions, esp. in patients with history of drug allergies, asthma; have epinephrine available. Avoid large IV doses: higher incidence of adverse events. Severe hepatic impairment. Avoid during acute phase of infectious kidney disease. Dialysis. Cardiovascular disease. May reactivate quiescent rheumatoid arthritis. Neonates. Pregnancy. Nursing mothers.
INFED Classification:
Hematinic.
INFED Interactions:
Concomitant ACE inhibitors may increase the risk for anaphylactic-type reactions. May falsely elevate serum bilirubin or decrease serum calcium levels.
Adverse Reactions:
See full labeling. Anaphylactic reactions (may be fatal; even if test dose was tolerated), cardiovascular events, pruritus, GI upset, arthralgia, arthritis, inj site reactions, others; possible IM inj site tumors, sepsis in neonates.
Generic Drug Availability:
NO
How Supplied:
Vials (2mL)—10
