Indomethacin Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Indomethacin Indications
Indications
Moderate to severe rheumatoid arthritis (including acute flares of chronic disease), osteoarthritis, ankylosing spondylitis. Acute painful shoulder (bursitis and/or tendinitis). Acute gouty arthritis.
Indomethacin Dosage and Administration
Adult
Children
Other Modifications
Females and Males of Reproductive Potential
-
Infertility for Females: Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs, including indomethacin, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consider withdrawal of NSAIDs, including indomethacin, in women who have difficulties conceiving or who are undergoing investigation of infertility.
Indomethacin Contraindications
Contraindications
Indomethacin Boxed Warnings
Boxed Warning
Indomethacin Warnings/Precautions
Warnings/Precautions
Indomethacin Pharmacokinetics
Absorption
Orally administered Indomethacin Capsules are virtually 100% bioavailable, with 90% of the dose absorbed within 4 hours. With a typical therapeutic regimen of 25 or 50 mg three times a day, the steady-state plasma concentrations of indomethacin are an average 1.4 times those following the first dose.
Distribution
Indomethacin is highly bound to protein in plasma (about 99%) over the expected range of therapeutic plasma concentrations. Indomethacin has been found to cross the blood-brain barrier and the placenta, and appears in breast milk.
Elimination
Indomethacin is eliminated via renal excretion, metabolism, and biliary excretion. Indomethacin undergoes appreciable enterohepatic circulation. About 60% of an oral dose is recovered in urine as drug and metabolites (26% as indomethacin and its glucuronide), and 33% is recovered in feces (1.5% as indomethacin). The mean half-life of indomethacin is estimated to be about 4.5 hours.