Inderal La Generic Name & Formulations
Legal Class
Rx
General Description
Propranolol HCl 60mg, 80mg, 120mg, 160mg; sust-rel caps.
Pharmacological Class
Beta-blocker.
See Also
How Supplied
Tabs—contact supplier; LA—100
Manufacturer
Mechanism of Action
Propranolol, a nonselective β-adrenergic receptor blocker, does not possess autonomic nervous system activity. Propranolol generally reduces the oxygen requirement of the heart at any given level of effort by blocking the catecholamine-induced increases in the heart rate, systolic blood pressure, and the velocity and extent of myocardial contraction.
Inderal La Indications
Indications
Long-term management of angina. Hypertrophic subaortic stenosis.
Inderal La Dosage and Administration
Adult
Angina: Initially 80mg once daily. May increase at 3–7 day intervals; max 320mg daily. Stenosis: 80–160mg once daily.
Children
Not recommended.
Inderal La Contraindications
Contraindications
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Inderal La Boxed Warnings
Not Applicable
Inderal La Warnings/Precautions
Warnings/Precautions
CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Inderal La Pharmacokinetics
Elimination
Renal. Half-life: 10hrs.
Inderal La Interactions
Interactions
Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.
Inderal La Adverse Reactions
Adverse Reactions
Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.
Inderal La Clinical Trials
See Literature
Inderal La Note
Not Applicable
Inderal La Patient Counseling
See Literature
Inderal La Generic Name & Formulations
Legal Class
Rx
General Description
Propranolol HCl 60mg, 80mg, 120mg, 160mg; sust-rel caps.
Pharmacological Class
Beta-blocker.
See Also
How Supplied
Tabs—contact supplier; LA—100
Manufacturer
Mechanism of Action
Propranolol, a nonselective β-adrenergic receptor blocker, does not possess autonomic nervous system activity. Its antihypertensive effect is thought to include: decreased cardiac output, inhibition of renin release by the kidneys, and diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain.
Inderal La Indications
Indications
Hypertension. Adjunct in pheochromocytoma.
Inderal La Dosage and Administration
Adult
Initially 80mg daily. Usual maintenance: 120–160mg daily; max 640mg daily.
Children
Not recommended.
Inderal La Contraindications
Contraindications
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Inderal La Boxed Warnings
Not Applicable
Inderal La Warnings/Precautions
Warnings/Precautions
CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Inderal La Pharmacokinetics
Elimination
Renal. Half-life: 3–6hrs.
Inderal La Interactions
Interactions
Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.
Inderal La Adverse Reactions
Adverse Reactions
Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.
Inderal La Clinical Trials
See Literature
Inderal La Note
Notes
Formerly known under the brand name Inderal.
Inderal La Patient Counseling
See Literature
Inderal La Generic Name & Formulations
Legal Class
Rx
General Description
Propranolol HCl 60mg, 80mg, 120mg, 160mg; sust-rel caps.
Pharmacological Class
Beta-blocker.
See Also
How Supplied
Tabs—contact supplier; LA—100
Manufacturer
Mechanism of Action
Propranolol, a nonselective β-adrenergic receptor blocker, does not possess autonomic nervous system activity. The mechanism of the antimigraine effect has not been established. β-adrenergic receptors have been demonstrated in the pial vessels of the brain.
Inderal La Indications
Indications
Migraine prophylaxis.
Inderal La Dosage and Administration
Adult
Initially 80mg daily. Usual range: 160–240mg daily. Discontinue if poor result after 4–6 weeks.
Children
Not recommended.
Inderal La Contraindications
Contraindications
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Inderal La Boxed Warnings
Not Applicable
Inderal La Warnings/Precautions
Warnings/Precautions
CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Inderal La Pharmacokinetics
Elimination
Renal. Half-life: 3–6hrs.
Inderal La Interactions
Interactions
Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.
Inderal La Adverse Reactions
Adverse Reactions
Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.
Inderal La Clinical Trials
See Literature
Inderal La Note
Notes
Formerly known under the brand name Inderal.
Inderal La Patient Counseling
See Literature