• Prostate and other male cancers

Ifex Generic Name & Formulations

General Description

Ifosfamide 1g, 3g; per vial; pwd for IV infusion after reconstitution.

Pharmacological Class

Alkylating agent.

How Supplied

Single-dose vials—1


Ifex Indications


Third-line adjunctive treatment of germ cell testicular cancer.

Ifex Dosage and Administration


Give by slow IV infusion over at least 30 mins. 1.2g/m2 per day for 5 consecutive days; repeat every 3 weeks or after hematological recovery (platelets ≥100000/µL, WBC ≥4000/µL).


Not recommended.

Ifex Contraindications


Urinary outflow obstruction.

Ifex Boxed Warnings

Boxed Warning

Myelosuppression. Neurotoxicity. Urotoxicity.

Ifex Warnings/Precautions


Risk of myelosuppression, immunosuppression, and infections. Do hematologic profile before each dose; discontinue if WBCs <2000/µL or platelets <50000/µL. Risk of CNS toxicity and other neurotoxic effects. Discontinue if encephalopathy develops. Do urinalysis before each dose, postpone dose if hematuria occurs. Give mesna and at least 2L fluids daily. Active urinary tract infections. Impaired hepatic, renal, or hematopoetic function. Preexisting cardiac disease. May interfere with wound healing. Prior radiation therapy or other cytotoxic agents. Ensure adequate hydration. Pregnancy (Cat.D); avoid. Nursing mothers: not recommended.

Ifex Pharmacokinetics

See Literature

Ifex Interactions


Increased risk of myelosuppression with other chemotherapy agents. Caution with drugs acting on the CNS (eg, antiemetics, sedatives, narcotics, antihistamines).

Ifex Adverse Reactions

Adverse Reactions

Alopecia, nausea, vomiting, leukopenia, anemia, CNS toxicity, hematuria, infection, renal or liver dysfunction, phlebitis, fever, urotoxicity (eg, hemorrhagic cystitis), thrombocytopenia, pulmonary toxicity, secondary malignancies.

Ifex Clinical Trials

See Literature

Ifex Note

Not Applicable

Ifex Patient Counseling

See Literature