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Hyperrab Generic Name & Formulations
Legal Class
Rx
General Description
Rabies immune globulin (human) 300 IU/mL; soln for IM inj; preservative-free; latex-free.
Pharmacological Class
Immune globulin.
How Supplied
Single-dose vial (1mL, 3mL, 5mL)—1
Manufacturer
Generic Availability
NO
Hyperrab Indications
Indications
Postexposure prophylaxis of rabies (along with rabies vaccine).
Hyperrab Dosage and Administration
Adult
See full labeling. Give by IM inj preferably at the time of 1st vaccine dose; may be given through 7th day after 1st vaccine dose is given. Not previously vaccinated: 20 IU/kg (0.0665mL/kg) once. If feasible, up to full dose should be infiltrated in area around wound and the rest (if any) into deltoid muscle of upper arm or lateral thigh muscle.
Children
Not established.
Hyperrab Contraindications
Not Applicable
Hyperrab Boxed Warnings
Not Applicable
Hyperrab Warnings/Precautions
Warnings/Precautions
Previously immunized with rabies vaccine with a confirmed adequate rabies antibody titer: not recommended. Contains human plasma; monitor for possible infection transmission. IgA-deficiency. Prior history of allergic reactions to human immunoglobulins. Have epinephrine inj available. Pregnancy. Nursing mothers.
Hyperrab Pharmacokinetics
See Literature
Hyperrab Interactions
Interactions
Do not administer repeated doses after administration of rabies vaccine; may suppress immune response to the vaccine. Avoid live vaccines for 4 months (eg, measles, mumps, polio, rubella).
Hyperrab Adverse Reactions
Adverse Reactions
Inj site pain or nodule, headache, abdominal pain, diarrhea, flatulence, nasal congestion, oropharyngeal pain; hypersensitivity reactions.
Hyperrab Clinical Trials
See Literature
Hyperrab Note
Not Applicable
Hyperrab Patient Counseling
See Literature
