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Hyperrab S/d Generic Name & Formulations
Legal Class
Rx
General Description
Rabies immune globulin (human) 150 IU/mL; soln for IM inj; preservative-free; latex-free.
Pharmacological Class
Immune globulin.
How Supplied
Single-dose vial (2mL, 10mL)—1
Manufacturer
Generic Availability
NO
Hyperrab S/d Indications
Indications
Postexposure prophylaxis of rabies (along with rabies vaccines).
Hyperrab S/d Dosage and Administration
Adult
See full labeling. Give by IM inj preferably at the time of 1st vaccine dose; may be given through 7th day after 1st vaccine dose is given. Not previously vaccinated: 20 IU/kg (0.133mL/kg) once. If feasible, up to full dose should be infiltrated in area around wound and the rest (if any) into deltoid muscle of upper arm or lateral thigh muscle.
Children
Not established.
Hyperrab S/d Contraindications
Not Applicable
Hyperrab S/d Boxed Warnings
Not Applicable
Hyperrab S/d Warnings/Precautions
Warnings/Precautions
Previously immunized with rabies vaccine with a confirmed adequate rabies antibody titer: not recommended. Contains human plasma; monitor for possible infection transmission. IgA-deficiency. Thrombocytopenia or other bleeding disorders. Prior history of allergic reactions to human immunoglobulins. Have epinephrine inj available. Pregnancy (Cat.C).
Hyperrab S/d Pharmacokinetics
See Literature
Hyperrab S/d Interactions
Interactions
Do not administer repeated doses after administration of rabies vaccine; may suppress immune response to the vaccine. Avoid live vaccines within 3 months (eg, measles, mumps, polio, rubella).
Hyperrab S/d Adverse Reactions
Adverse Reactions
Inj site reactions, mild temp elevations; rare: angioneurotic edema, rash, nephrotic syndrome, anaphylactic shock.
Hyperrab S/d Clinical Trials
See Literature
Hyperrab S/d Note
Not Applicable
Hyperrab S/d Patient Counseling
See Literature
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