Hyperrab S/d

  • Vaccines

Hyperrab S/d Generic Name & Formulations

General Description

Rabies immune globulin (human) 150 IU/mL; soln for IM inj; preservative-free; latex-free.

Pharmacological Class

Immune globulin.

How Supplied

Single-dose vial (2mL, 10mL)—1

Generic Availability


Hyperrab S/d Indications


Postexposure prophylaxis of rabies (along with rabies vaccines).

Hyperrab S/d Dosage and Administration


See full labeling. Give by IM inj preferably at the time of 1st vaccine dose; may be given through 7th day after 1st vaccine dose is given. Not previously vaccinated: 20 IU/kg (0.133mL/kg) once. If feasible, up to full dose should be infiltrated in area around wound and the rest (if any) into deltoid muscle of upper arm or lateral thigh muscle.


Not established.

Hyperrab S/d Contraindications

Not Applicable

Hyperrab S/d Boxed Warnings

Not Applicable

Hyperrab S/d Warnings/Precautions


Previously immunized with rabies vaccine with a confirmed adequate rabies antibody titer: not recommended. Contains human plasma; monitor for possible infection transmission. IgA-deficiency. Thrombocytopenia or other bleeding disorders. Prior history of allergic reactions to human immunoglobulins. Have epinephrine inj available. Pregnancy (Cat.C).

Hyperrab S/d Pharmacokinetics

See Literature

Hyperrab S/d Interactions


Do not administer repeated doses after administration of rabies vaccine; may suppress immune response to the vaccine. Avoid live vaccines within 3 months (eg, measles, mumps, polio, rubella).

Hyperrab S/d Adverse Reactions

Adverse Reactions

Inj site reactions, mild temp elevations; rare: angioneurotic edema, rash, nephrotic syndrome, anaphylactic shock.

Hyperrab S/d Clinical Trials

See Literature

Hyperrab S/d Note

Not Applicable

Hyperrab S/d Patient Counseling

See Literature