Hydralazine Injection Generic Name & Formulations
Hydralazine (as HCl) 20mg/mL; IM or IV inj; contains parabens.
Hydralazine Injection Indications
Severe essential hypertension when oral therapy not feasible or there is an urgent need to lower blood pressure.
Hydralazine Injection Dosage and Administration
Monitor BP closely. 20–40mg; repeat as needed. Advanced renal damage: reduce dose.
Not recommended; doses of 1.7–3.5mg/kg per day in 4–6 divided doses have been used.
Hydralazine Injection Contraindications
Coronary artery disease. Mitral valve disease.
Hydralazine Injection Boxed Warnings
Hydralazine Injection Warnings/Precautions
Suspected coronary artery disease. Cerebrovascular accidents. Aortic aneurysm. Increased intracranial pressure. Renal disease. Treat paresthesias and/or numbness with pyridoxine. Discontinue if blood dyscrasias occur. Obtain CBC and ANA titer periodically; consider discontinuing if SLE occurs. Surgery. Pregnancy (Cat.C). Nursing mothers.
Hydralazine Injection Pharmacokinetics
Hydralazine Injection Interactions
Caution with MAOIs. Profound hypotension with potent parenteral antihypertensives (eg, diazoxide). Antagonized by NSAIDs. May block epinephrine.
Hydralazine Injection Adverse Reactions
Headache, anorexia, GI disturbances, palpitations, edema, flushing, nasal congestion, lacrimation, rash, tachycardia, angina, orthostatic hypotension, blood dyscrasias, peripheral neuritis, SLE.
Hydralazine Injection Clinical Trials
Hydralazine Injection Note
Formerly known under the brand names Apresoline (inj, tabs); Dralzine (tabs).
Hydralazine Injection Patient Counseling