Humulin 70/30

  • Diabetes

Humulin 70/30 Generic Name & Formulations

General Description

Insulin isophane suspension (NPH) 70% (human, rDNA origin), regular insulin 30% (human, rDNA origin) 100 Units/mL; inj.

How Supplied

Vials 70/30, N, R (U-100)—3mL, 10mL; R (U-500)—20mL; KwikPen (70/30, N)—5x3mL; R (U-500)—2x3mL


Humulin 70/30 Indications



Humulin 70/30 Dosage and Administration


≥18yrs: Individualize. SC inj only. Rotate inj sites. Onset 30–90mins, peak 1.5–6.5hrs, duration 18–24hrs.


<18yrs: not established.

Humulin 70/30 Contraindications


During episodes of hypoglycemia.

Humulin 70/30 Boxed Warnings

Not Applicable

Humulin 70/30 Warnings/Precautions


Instruct patients on proper administration of insulin, check insulin label before each injection, and management of hypoglycemia. Do not reuse or share pens, needles, or syringes between patients, even if the needle is changed. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis. Increased risk of hyperglycemia or hypoglycemia if changes in physical activity, meal patterns, concomitant medications, renal or hepatic function, insulin regimen, administration site, and if acute illness occurs: monitor glucose more frequently and may need to adjust dose. Monitor potassium levels in patients at risk for hypokalemia (eg, concomitant K+-lowering or K+-sensitive drugs). Discontinue if hypersensitivity reactions occur. Renal or hepatic impairment. Elderly. Pregnancy. Nursing mothers.

Humulin 70/30 Pharmacokinetics

See Literature

Humulin 70/30 Interactions


Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Increased risk of hypoglycemia with concomitant antidiabetics, ACEIs, ARBs, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (eg, octreotide), sulfonamide antibiotics. Reduced efficacy with concomitant atypical antipsychotics (eg, olanzapine, clozapine), steroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, protease inhibitors, somatropin, sympathomimetics (eg, albuterol, epinephrine, terbutaline), thyroid hormones. Variable effects with β-blockers, clonidine, lithium salts, alcohol, pentamidine. Concomitant β-blockers, clonidine, guanethidine, reserpine may blunt hypoglycemia. Onset may be delayed if regular insulin is mixed with zinc insulin. Regular and NPH insulins may be mixed and used immediately or stored for future use.

Humulin 70/30 Adverse Reactions

Adverse Reactions

Hypoglycemia, allergic reactions, inj site reactions, lipodystrophy, pruritus, rash, weight gain, edema, hypokalemia.

Humulin 70/30 Clinical Trials

See Literature

Humulin 70/30 Note

Not Applicable

Humulin 70/30 Patient Counseling

See Literature