Humulin 70/30 Generic Name & Formulations
Insulin isophane suspension (NPH) 70% (human, rDNA origin), regular insulin 30% (human, rDNA origin) 100 Units/mL; inj.
Vials 70/30, N, R (U-100)—3mL, 10mL; R (U-500)—20mL; KwikPen (70/30, N)—5x3mL; R (U-500)—2x3mL
Humulin 70/30 Indications
Humulin 70/30 Dosage and Administration
≥18yrs: Individualize. SC inj only. Rotate inj sites. Onset 30–90mins, peak 1.5–6.5hrs, duration 18–24hrs.
<18yrs: not established.
Humulin 70/30 Contraindications
During episodes of hypoglycemia.
Humulin 70/30 Boxed Warnings
Humulin 70/30 Warnings/Precautions
Instruct patients on proper administration of insulin, check insulin label before each injection, and management of hypoglycemia. Do not reuse or share pens, needles, or syringes between patients, even if the needle is changed. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis. Increased risk of hyperglycemia or hypoglycemia if changes in physical activity, meal patterns, concomitant medications, renal or hepatic function, insulin regimen, administration site, and if acute illness occurs: monitor glucose more frequently and may need to adjust dose. Monitor potassium levels in patients at risk for hypokalemia (eg, concomitant K+-lowering or K+-sensitive drugs). Discontinue if hypersensitivity reactions occur. Renal or hepatic impairment. Elderly. Pregnancy. Nursing mothers.
Humulin 70/30 Pharmacokinetics
Humulin 70/30 Interactions
Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Increased risk of hypoglycemia with concomitant antidiabetics, ACEIs, ARBs, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (eg, octreotide), sulfonamide antibiotics. Reduced efficacy with concomitant atypical antipsychotics (eg, olanzapine, clozapine), steroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, protease inhibitors, somatropin, sympathomimetics (eg, albuterol, epinephrine, terbutaline), thyroid hormones. Variable effects with β-blockers, clonidine, lithium salts, alcohol, pentamidine. Concomitant β-blockers, clonidine, guanethidine, reserpine may blunt hypoglycemia. Onset may be delayed if regular insulin is mixed with zinc insulin. Regular and NPH insulins may be mixed and used immediately or stored for future use.
Humulin 70/30 Adverse Reactions
Hypoglycemia, allergic reactions, inj site reactions, lipodystrophy, pruritus, rash, weight gain, edema, hypokalemia.
Humulin 70/30 Clinical Trials
Humulin 70/30 Note
Humulin 70/30 Patient Counseling