Heparin Sodium

  • Thromboembolic disorders

Heparin Sodium Generic Name & Formulations

General Description

Heparin sodium 1000, 5000, 10000units; per mL; IV or SC inj; preservative-free or preserved with benzyl alcohol.

Pharmacological Class


How Supplied

Contact supplier.

Heparin Sodium Indications


Anticoagulation therapy.

Heparin Sodium Dosage and Administration

Adults and Children

See full labeling. Individualize based on lab results and disease.

Heparin Sodium Contraindications


History of heparin-induced thrombocytopenia (HIT) or heparin-induced thrombocytopenia and thrombosis (HITT). History of thrombocytopenia with pentosan polysulfate. Hypersensitivity to pork products. When blood coagulation testing is not feasible. Uncontrolled bleeding state, except when due to disseminated intravascular coagulation.

Heparin Sodium Boxed Warnings

Not Applicable

Heparin Sodium Warnings/Precautions


IM use not recommended. Confirm choice of correct strength prior to administration. Monitor for any degree of thrombocytopenia; discontinue if platelet count falls <100000/mm3 or if recurrent thrombosis develops; evaluate for HIT and HITT; if needed, give alternative anticoagulant. Major bleeding or conditions with increased risk of hemorrhage (eg, bacterial endocarditis, severe hypertension, surgery, hemophilia, hereditary antithrombin III deficiency receiving concurrent antithrombin III therapy, ulcerative lesions, continuous GI tube drainage, menstruation, liver disease with impaired hemostasis). Monitor blood coagulation tests (discontinue if test is unduly prolonged or if hemorrhage occurs), platelets, hematocrit, and occult blood in stool during therapy, regardless of the route of administration. Heparin resistance (monitor). History of allergy. Not interchangeable (unit-for-unit) with low molecular weight heparins. Women >60yrs of age. Elderly. Neonates/infants (gasping syndrome due to benzyl alcohol), pregnancy, nursing mothers: use preservative-free formulations.

Heparin Sodium Pharmacokinetics

See Literature

Heparin Sodium Interactions


Potentiated by anticoagulants (eg, dicumerol, warfarin), antiplatelets (eg, salicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, celecoxib, thienopyridines, dipyridamole, hydroxychloroquine, glycoprotein IIb/IIIa antagonists including abciximab, eptifibatide, tirofiban) and others; caution. Antagonized by digitalis, tetracyclines, nicotine, antihistamines, IV nitroglycerin. Potentiated by concurrent treatment with antithrombin III (human) in patients with hereditary antithrombin III deficiency; reduce heparin dose.

Heparin Sodium Adverse Reactions

Adverse Reactions

Hemorrhage, thrombocytopenia, HIT and HITT, inj site irritation, hypersensitivity reactions, increased aminotransferase levels.

Heparin Sodium Clinical Trials

See Literature

Heparin Sodium Note


Formerly known under the brand names Panheparin, Lipo-Hepin, Liquaemin.

Heparin Sodium Patient Counseling

See Literature