• Sleep-wake disorders

Halcion Generic Name & Formulations

General Description

Triazolam 0.25mg; scored tabs.

Pharmacological Class


How Supplied

Tabs—10, 100


Generic Availability


Halcion Indications


Short-term (7–10 days) treatment of insomnia.

Halcion Dosage and Administration


Use lowest effective dose. 0.125–0.25mg at bedtime; max 0.5mg. Elderly: initially 0.125mg; max 0.25mg. Reevaluate if used ≥3 weeks. Max 1 month/℞.


Not established.

Halcion Contraindications


Concomitant strong CYP3A inhibitors (eg, ketoconazole, itraconazole, clarithromycin, nefazodone, ritonavir, indinavir, nelfinavir, saquinavir, lopinavir, grapefruit juice).

Halcion Boxed Warnings

Boxed Warning

Risks from concomitant use with opioids. Abuse, misuse, and addiction. Dependence and withdrawal reactions.

Halcion Warnings/Precautions


Increased risk of drug-related mortality from concomitant use with opioids. Evaluate for co-morbid diagnoses (eg, physical and/or psychiatric disorders) prior to treatment. Reevaluate if insomnia fails to remit after 7–10 days of use. Depression. Suicidal tendencies. Evaluate any new onset of behavioral changes. Compromised respiratory function (monitor); consider discontinuing if respiratory depression or apnea occurs. Assess patient's risk for abuse, misuse, addiction prior to and during therapy. Avoid abrupt cessation. Withdraw gradually. Drug or alcohol abusers. Elderly (higher risk of falls). Neonates. Pregnancy. Nursing mothers: monitor infants (consider interrupting breastfeeding or pumping/discarding breast milk during and for 28hrs after dose).

Halcion Pharmacokinetics

See Literature

Halcion Interactions


See Contraindications. Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Additive CNS depressant effects with alcohol or other CNS depressants (eg, other benzodiazepines, psychotropics, anticonvulsants, antihistamines); consider dose reductions. Potentiated by moderate/weak CYP3A inhibitors (eg, erythromycin, cimetidine, isoniazid, oral contraceptives, ranitidine); consider reducing triazolam dose. Caution with fluvoxamine, diltiazem, verapamil, sertraline, paroxetine, ergotamine, cyclosporine, amiodarone, nicardipine, nifedipine.

Halcion Adverse Reactions

Adverse Reactions

Drowsiness, headache, dizziness, nervousness, light-headedness, ataxia, nausea, vomiting; worsening of insomnia, complex behaviors (eg, sleep-driving), daytime anxiety (discontinue if worsens), anterograde amnesia, paradoxical reactions, withdrawal reactions.

Halcion Clinical Trials

See Literature

Halcion Note

Not Applicable

Halcion Patient Counseling

See Literature